Tulipaline A: Structure-activity aspects as a nematicide and V-ATPase inhibitor (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Tulipaline A: Structure-activity aspects as a nematicide and V-ATPase inhibitor (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.pestbp.2014.05.002 (literal)

Alternative label

• Caboni P., Tronci L., Liori B., Tocco G., Sasanelli N., Diana A. (2014)
  Tulipaline A: Structure-activity aspects as a nematicide and V-ATPase inhibitor
  in Pesticide biochemistry and physiology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Caboni P., Tronci L., Liori B., Tocco G., Sasanelli N., Diana A. (literal)

Pagina inizio

• 33 (literal)

Pagina fine

• 39 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-84903145325&partnerID=q2rCbXpz (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 112 (literal)

Rivista

• Pesticide biochemistry and physiology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Caboni P., Tronci L., Liori B., Tocco G.: Department of Life and Environmental Sciences, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy; Diana A.: Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy (literal)

Titolo

• Tulipaline A: Structure-activity aspects as a nematicide and V-ATPase inhibitor (literal)

Abstract

• Carbonyl groups are known to form covalent adducts with endogenous proteins, but so far, their nematicidal mechanism of action of has been overlooked. The nematicidal activity of ten lactones was tested in vitro against the root knot nematodes Meloidogyne incognita and Meloidogyne arenaria. In particular, the saturated lactones alpha-methylene-gamma-butyrolactone or tulipaline A (1) and gamma-butyrolactone (3) were active against M. incognita with an EC50/48h of 19.3 +/- 10.0 and 40.0 +/- 16.2 mg/L respectively. Moreover the alpha, beta-unsaturated lactone 5,6-dihydro-2H-pyran-2-one (2) exhibited the strongest nematicidal activity against the two species with EC50/48h 14.5 +/- 5.3 and 21.2 +/- 9.7 mg/L respectively. Here we propose that the toxic effects of lactones and aldehydes on M. incognita and M. arenaria might be a consequence of their vacuolar-type H+-ATPase (V-ATPase) inhibition activity; in fact alpha-methylene-gamma-butyrolactone (1) and salicylaldehyde (12) produced an increased pH in lysosomal-like organelles on HeLa human cell line and this alteration was most likely related to a V-ATPase impairment (literal)

Prodotto di

• Tecnologie ecosostenibili per la protezione delle piante dagli agenti di danno (AG.P04.026.001) (Modulo)
• Istituto per la protezione delle piante (IPP) (Istituto)

Autore CNR

• NICOLA SASANELLI (Persona)

Insieme di parole chiave

• Parole chiave di "Tulipaline A: Structure-activity aspects as a nematicide and V-ATPase inhibitor" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• NICOLA SASANELLI (Persona)

Prodotto

• Istituto per la protezione delle piante (IPP) (Istituto)
• Tecnologie ecosostenibili per la protezione delle piante dagli agenti di danno (AG.P04.026.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Pesticide biochemistry and physiology (Rivista)

Insieme di parole chiave di

• Parole chiave di "Tulipaline A: Structure-activity aspects as a nematicide and V-ATPase inhibitor" (Insieme di parole chiave)