http://www.cnr.it/ontology/cnr/individuo/prodotto/ID287810

Q192R paraoxonase (PON)1 polymorphism, insulin sensitivity, and endothelial function in essential hypertensive men (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Q192R paraoxonase (PON)1 polymorphism, insulin sensitivity, and endothelial function in essential hypertensive men (Articolo in rivista) (literal)

Anno

2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.4137/CMC.S15493 (literal)

Alternative label

Dell'Omo G.; Penno G.; Pucci L.; Lucchesi D.; Del Prato S.; Pedrinelli R. (2014)
Q192R paraoxonase (PON)1 polymorphism, insulin sensitivity, and endothelial function in essential hypertensive men
in Clinical medicine insights. Cardiology
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Dell'Omo G.; Penno G.; Pucci L.; Lucchesi D.; Del Prato S.; Pedrinelli R. (literal)

Pagina inizio

57 (literal)

Pagina fine

62 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.scopus.com/inward/record.url?eid=2-s2.0-84904347401&partnerID=q2rCbXpz (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

8 (literal)

Rivista

Clinical medicine insights. Cardiology (Rivista)

Note

Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Dipartimenti di Patologia Chirurgica, Medica, Molecolare e dell'Area Critica, Pisa, Italy; Medicina Clinica e Sperimentale, Università di Pisa, Pisa, Italy; Istituto di Biologia e Biotecnologia Agraria, CNR, Pisa, Italy (literal)

Titolo

Q192R paraoxonase (PON)1 polymorphism, insulin sensitivity, and endothelial function in essential hypertensive men (literal)

Abstract

AIMS: Essential hypertension is characterized by increased reactive oxygen species (ROS) generation harmful for insulin sensitivity and nitric oxide (NO)-mediated vasomotor function, a noxious effect that paraoxonase (PON)1, an antioxidant circulating high-density lipoprotein (HDL)-bound esterase, may counteract. The PON1 gene contains several polymorphisms including a glutamine (Q) to arginine (R) transition at position 192 encoding circulating allozymes with higher antioxidant activity that might influence both parameters. METHODS: Q192R was determined by polymerase chain reaction in 72 never-treated, glucose-tolerant, uncomplicated essential hypertensive men. Insulin sensitivity was assessed by homeostasis model assessment (HOMA) and endothelial function by forearm vasodilation (strain-gage venous plethys-mography) to intra-arterial acetylcholine (ACH) with sodium nitroprusside (NIP) as a NO-independent control. Additional evaluation variables included 24-hour blood pressure (BP), lipids, BMI, smoking status, and metabolic syndrome (MetS) by Adult Treatment Panel (ATP)-III criteria. R192 was con-sidered as the rare allele, and its associations analyzed by dominant models (Q/Q vs. Q/R + R/R). RESULTS: Genotype frequencies were consistent with the Hardy-Weinberg equilibrium. HOMA was lower and insulin resistance (the upper fourth of HOMA values distribution) less prevalent in Q/R + R/R carriers in whom ACH-mediated vasodilatation was greater and endothelial dysfunction (the bottom fourth of ACHAUC values distribution) less frequent than in Q/Q homozygotes. Q192R polymorphism and MetS were unrelated parameters despite their common association with insulin resistance. 24-hour BP, BMI, lipids, and smoking habits were homogeneously distributed across genotypes. CONCLUSIONS: Q192R polymorphism associates differentially with insulin sensitivity and endothelial function in essential hypertensive men. © the authors, publisher and licensee Libertas Academica Limited. (literal)

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