High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.4161/cbt.28408 (literal)

Alternative label

• Cirillo A.; Di Salle A.; Petillo O.; Melone M.A.B.; Grimaldi G.; Bellotti A.; Torelli G.; De'Santi M.S.; Cantatore G.; Marinelli A.; Galderisi U.; Peluso G. (2014)
  High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism
  in Cancer biology & therapy (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Cirillo A.; Di Salle A.; Petillo O.; Melone M.A.B.; Grimaldi G.; Bellotti A.; Torelli G.; De'Santi M.S.; Cantatore G.; Marinelli A.; Galderisi U.; Peluso G. (literal)

Pagina inizio

• 735 (literal)

Pagina fine

• 741 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-84901722804&partnerID=q2rCbXpz (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 15 (literal)

Rivista

• Cancer biology & therapy (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 6 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Biomedicine and Bioresources, CNR, Naples, Italy; Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy; Institute of Genetics and Biophysics Adriano Buzzati-Traverso, CNR, Naples, Italy; UOC of Neurosurgery, AORN of Caserta, Caserta, Italy; UOC of Neurosurgery, AO Rummo, Benevento, Italy; Neurosurgery Division, PO Umberto I, Nocera Inferiore, Italy; PO Santa Maria di Loreto Mare, Napoli, Italy; UO of Neurosurgery, AOU San Giovanni di Dio e Ruggi di Aragona, Salerno, Italy; Department of Endocrinology and Clinical and Molecular Oncology, University Federico II, Naples, Italy; Department of Experimental Medicine, Second University of Naples, Naples, Italy (literal)

Titolo

• High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism (literal)

Abstract

• The diagnosis of glioblastoma is still based on tumor histology, but emerging molecular diagnosis is becoming an important part of glioblastoma classification. Besides the well-known cell cycle-related circuitries that are associated with glioblastoma onset and development, new insights may be derived by looking at pathways involved in regulation of epigenetic phenomena and cellular metabolism, which may both be highly deregulated in cancer cells. We evaluated if in glioblastoma patients the high grade of malignancy could be associated with aberrant expression of some genes involved in regulation of epigenetic phenomena and lipid metabolism. We measured the mRNA levels of ZFP57, TRIM28, CPT1A, CPT1B, and CPT1C in a cohort of 80 patients divided in two groups: grade II and grade IV. We evidenced that high grade glioblastoma is associated with increased level of ZFP57, a protein involved in gene imprinting, and aberrant expression of CPT1A and CPT1C, regulators of fatty acid oxidation. Our study may pave the way to identify new markers that could be potentially useful for diagnosis and/or prognosis of glioblastoma. © 2014 Landes Bioscience. (literal)

Prodotto di

• Plasticità genomica: dal genoma ai sistemi biologici (SV.P13.003.001) (Modulo)
• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR

• GIOVANNA GRIMALDI (Persona)
• ANNA DI SALLE (Unità di personale interno)

Insieme di parole chiave

• Keywords of "High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Plasticità genomica: dal genoma ai sistemi biologici (SV.P13.003.001) (Modulo)

Autore CNR di

• GIOVANNA GRIMALDI (Persona)
• ANNA DI SALLE (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cancer biology & therapy (Rivista)

Insieme di parole chiave di

• Keywords of "High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism" (Insieme di parole chiave)