Integrated analysis of DNA copy number and gene expression data in Lung cancer models of resistance to targeted therapy (Abstract/Comunicazione in atti di convegno)

Type
Label
  • Integrated analysis of DNA copy number and gene expression data in Lung cancer models of resistance to targeted therapy (Abstract/Comunicazione in atti di convegno) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Alternative label
  • Fustaino V(1),(2), Felici G(2) and Ruberti G(1) (2014)
    Integrated analysis of DNA copy number and gene expression data in Lung cancer models of resistance to targeted therapy
    in IV EURO WG Conference on Operational Research in Computational Biology, Bioinformatics and Medicine, Pozna? - Biedrusko, Polonia, 26-28 Giugno 2014
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Fustaino V(1),(2), Felici G(2) and Ruberti G(1) (literal)
Note
  • Comunicazione (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • (1) Istituto di Biologia Cellulare e Neurobiologia (IBCN), Consiglio Nazionale delle Ricerche (CNR) Monterotondo (RM), Italy (2) Istituto di Analisi dei Sistemi ed Informatica \"Antonio Ruberti\" (IASI), CNR, Roma, Italy (literal)
Titolo
  • Integrated analysis of DNA copy number and gene expression data in Lung cancer models of resistance to targeted therapy (literal)
Abstract
  • Tyrosine Kinase inhibitors (TKIs) constitute the most promising frontier of cancer treatment. However, the development of resistance mechanisms often makes the tumour insensitive to TKI-targeted therapy. The present work aims to identify genes and pathways involved in TKI-resistance. To this end, we developed cellular models of NSCLC and designed cellular, molecular and bioinformatics analyses. Preliminary functional enrichment analysis of genes, found consistently altered in resistant cell lines, indicates their involvement in key biological processes. (literal)
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
data.CNR.it