Low serum testosterone as a new risk factor for chronic rejection in heart transplanted men (Articolo in rivista)

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  • Low serum testosterone as a new risk factor for chronic rejection in heart transplanted men (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1097/TP.0b013e31829b0893 (literal)
Alternative label
  • Caretta N.; Feltrin G.; Tarantini G.; D'Agostino C.; Tona F.; Selice R.; Krajcar T.; Minicuci N.; Gerosa G.; Foresta C. (2013)
    Low serum testosterone as a new risk factor for chronic rejection in heart transplanted men
    in Transplantation
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Caretta N.; Feltrin G.; Tarantini G.; D'Agostino C.; Tona F.; Selice R.; Krajcar T.; Minicuci N.; Gerosa G.; Foresta C. (literal)
Pagina inizio
  • 501 (literal)
Pagina fine
  • 505 (literal)
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  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84883557008&partnerID=q2rCbXpz (literal)
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  • 96 (literal)
Rivista
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  • 5 (literal)
Note
  • Scopu (literal)
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  • Department of Molecular Medicine, Centre for Human Reproduction Pathology, University of Padova, Via Giustiniani 2 c/o Palafellin, 35121 Padova, Italy; Department of Cardiovascular Surgery, University of Padova, Padova, Italy; Division of Cardiology, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy; National Council Research, Institute of Neuroscience, Padova, Italy (literal)
Titolo
  • Low serum testosterone as a new risk factor for chronic rejection in heart transplanted men (literal)
Abstract
  • BACKGROUND: Among the various complications of heart transplantation (HTx), the vasculopathy of the allograft (CAV), a phenomenon of chronic rejection, is still a serious problem. Recently, the literature has shown that low testosterone levels in men are associated with cardiovascular disease. In this study, we evaluated the influence of testosterone plasma levels on CAV development. METHODS: We studied, with a prospective observational study, all consecutive male HTx patients evaluated from May 2010 to June 2011 at our center. All subjects underwent accurate medical history collection, physical examination, biochemical blood tests, hormone levels, transthoracic Doppler echocardiography, coronary flow velocity reserve assessment, and coronary angiogram. RESULTS: HTx subjects with CAV had significant lower total testosterone plasma levels (12.9±3.9 vs. 15.8±5.8 nmol/L), free testosterone (0.26±0.07 vs. 0.31±0.08 nmol/L), and coronary flow velocity reserve (2.35±0.60 vs. 2.81±0.78 s) with respect to No-CAV patients. Considering the patients as a whole group, a significant negative relation was found between free and total testosterone plasma levels and some cardiovascular risk factors (cholesterol and fasting blood glucose). A significant linear inverse relation was found between total and free testosterone plasma levels and CAV grading. Only free testosterone plasma levels were independent predictors for CAV. CONCLUSIONS: We showed for the first time the influence of testosterone plasma levels on CAV development: indirectly increasing traditional risk factors and directly with a probable influence on alloimmune response.Copyright © 2013 by Lippincott Williams & Wilkins. (literal)
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