Pro-Oxidative Action of Polyphenols as Action Mechanism for their Pro-Apoptotic Activity (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Pro-Oxidative Action of Polyphenols as Action Mechanism for their Pro-Apoptotic Activity (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.2174/1871520614666140922121014 (literal)

Alternative label

• Lecci Raffaella Marina, Logrieco Antonio, Leone Antonella. (2014)
  Pro-Oxidative Action of Polyphenols as Action Mechanism for their Pro-Apoptotic Activity
  in Anti-cancer agents in medicinal chemistry (Online); Bentham Science Publishers Ltd., Sharjah (Emirati Arabi Uniti)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Lecci Raffaella Marina, Logrieco Antonio, Leone Antonella. (literal)

Pagina inizio

• 1363 (literal)

Pagina fine

• 1375 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Impact Factor: 2.939 Reperibile in: http://www.ingentaconnect.com/content/ben/acamc/2014/00000014/00000010/art00008 http://europepmc.org/abstract/med/25244914 http://www.ncbi.nlm.nih.gov/pubmed/25244914 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.eurekaselect.com/124803/article (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 14 (literal)

Rivista

• Anti-cancer agents in medicinal chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 13 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 10 (literal)

Note

• Google Scholar (literal)
• ISI Web of Science (WOS) (literal)
• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• National Research Council, Institute of Sciences of Food Production, (CNR, ISPA), Unit of Lecce Via Prov.le Lecce-Monteroni, 73100, Lecce, Italy (literal)

Titolo

• Pro-Oxidative Action of Polyphenols as Action Mechanism for their Pro-Apoptotic Activity (literal)

Abstract

• Polyphenols, secondary metabolites widely present in plant kingdom, are known for their positive effects on human health, such as treatments of degenerative disease and cancer. Many dietary polyphenols show anti-inflammatory, immunomodulatory and anti-oxidant properties and they are proposed as chemopreventive agents for many skin disorders and cancer. Exposure to solar UV radiation is widely considered to cause skin cancer and a consistent carcinogenic dose derives from UVA, causing several skin disorders as consequence of free radicals generation and DNA damages. Polyphenols, secondary metabolites widely present in plant kingdom, are known for their positive effects on human health, such as treatments of degenerative disease and cancer. Many dietary polyphenols show anti-inflammatory, immunomodulatory and anti-oxidant properties and they are proposed as chemopreventive agents for many skin disorders and cancer. Exposure to solar UV radiation is widely considered to cause skin cancer and a consistent carcinogenic dose derives from UVA, causing several skin disorders as consequence of free radicals generation and DNA damages. In this study, verbascoside, isoverbascoside and tyrosol were investigated for their effect on HEKa (Human Epidermal Keratinocytes adult) cell cultures challenged from UVA-rays. Non-toxic doses of each polyphenol were assayed on HEKa before, during and after the exposure to a damaging dose of UVA: the treatment on HEKa UVA-irradiated caused a decrease of cell viability. Treatment with polyphenols before and after the UVA-irradiation exerted a pro-oxidant effect, while the simultaneous treatment caused a weak decrease of ROS production. The increasing of ROS levels was associated with a pro-apoptotic effect on HEKa, detected by AnnexinV/Propidiun Iodide, mainly evident in surviving cells treated with the polyphenols after the UVA-irradiation. The pro-apoptotic effect was confirmed by the immunodetection of significant changes in the Bax and Bcl-xL protein levels, leading to apoptotic events. The hypothesis that these polyphenols could trigger the apoptosis pathway mainly in UVA-damaged cells, via ROS increase, is here proposed as action mechanism behind their protective effect. (literal)

Editore

• Bentham Science Publishers Ltd. (Editore)

Prodotto di

• Istituto di scienze delle produzioni alimentari (ISPA) (Istituto)
• Biotecnologie per la qualità e sicurezza degli alimenti (AG.P05.007.001) (Modulo)

Autore CNR

• ANTONELLA LEONE (Unità di personale interno)
• ANTONIO FRANCESCO LOGRIECO (Persona)
• Raffaella Marina Lecci (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Pro-Oxidative Action of Polyphenols as Action Mechanism for their Pro-Apoptotic Activity" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANTONIO FRANCESCO LOGRIECO (Persona)
• ANTONELLA LEONE (Unità di personale interno)
• Raffaella Marina Lecci (Unità di personale esterno)

Prodotto

• Istituto di scienze delle produzioni alimentari (ISPA) (Istituto)
• Biotecnologie per la qualità e sicurezza degli alimenti (AG.P05.007.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Anti-cancer agents in medicinal chemistry (Rivista)

Editore di

• Bentham Science Publishers Ltd. (Editore)

Insieme di parole chiave di

• Keywords of "Pro-Oxidative Action of Polyphenols as Action Mechanism for their Pro-Apoptotic Activity" (Insieme di parole chiave)