Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the beta-class (PgiCAb) versus the gamma-class (PgiCA) enzymes. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the beta-class (PgiCAb) versus the gamma-class (PgiCA) enzymes. (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.bmc.2014.07.048 (literal)

Alternative label

• Prete, Sonia Del; Vullo, Daniela; Osman, Sameh M; Scozzafava, Andrea; AlOthman, Zeid; Capasso, Clemente; Supuran, Claudiu T (2014)
  Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the beta-class (PgiCAb) versus the gamma-class (PgiCA) enzymes.
  in Bioorganic & medicinal chemistry (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Prete, Sonia Del; Vullo, Daniela; Osman, Sameh M; Scozzafava, Andrea; AlOthman, Zeid; Capasso, Clemente; Supuran, Claudiu T (literal)

Pagina inizio

• 4537 (literal)

Pagina fine

• 43 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 22 (literal)

Rivista

• Bioorganic & medicinal chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 17 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR - IBBR - Napoli (literal)

Titolo

• Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the beta-class (PgiCAb) versus the gamma-class (PgiCA) enzymes. (literal)

Abstract

• The oral pathogenic bacterium Porphyromonas gingivalis, encodes for two carbonic anhydrases (CAs, EC 4.2.1.1) one belonging to the gamma-class (PgiCA) and another one to the beta-class (PgiCAb). This last enzyme has been cloned and characterized here for its inhibition profile with the main class of CA inhibitors, the sulfonamides. Many of the clinically used sulfonamides as well as simple aromatic/heterocyclic sulfonamides were ineffective as PgiCAb inhibitors whereas better inhibition was observed with simple derivatives such as sulfanilamide, metanilamide, 4-aminoalkylbenzenesulfonamides (KIs of 364-475nM). The halogenosulfanilamides incorporating heavy halogens, 4-hydroxy- and 4-hydroxyalkyl-benzenesulfonamides, were also micromolar, ineffective PgiCAb inhibitors. The best inhibitors of the beta-class enzyme were acetazolamide and ethoxzolamide, with KIs of 214-280nM. Interestingly, the gamma-class enzyme was much more sensitive to sulfonamide inhibitors compared to the beta-class one, PgiCAb. Identification of potent and possibly selective inhibitors of PgiCAb/PgiCA may lead to pharmacological tools useful for understanding the physiological role(s) of these enzymes, since this bacterium is the main causative agent of periodontitis and few treatment options are presently available. (literal)

Prodotto di

• DR. PELUSO: Nanotecnologie applicate alla terapia genica e cellulare (PM.P02.014.001) (Modulo)
• Istituto di Bioscienze e Biorisorse (IBBR) (Istituto)

Autore CNR

• CLEMENTE CAPASSO (Unità di personale interno)

Incoming links:

Autore CNR di

• CLEMENTE CAPASSO (Unità di personale interno)

Prodotto

• Istituto di Bioscienze e Biorisorse (IBBR) (Istituto)
• DR. PELUSO: Nanotecnologie applicate alla terapia genica e cellulare (PM.P02.014.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Bioorganic & medicinal chemistry (Rivista)