A PSA-guided approach for a better diagnosis of prostatic adenocarcinoma based on MALDI profiling and peptide identification. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• A PSA-guided approach for a better diagnosis of prostatic adenocarcinoma based on MALDI profiling and peptide identification. (Articolo in rivista) (literal)

Anno

• 2015-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.cca.2014.10.003. (literal)

Alternative label

• Chiara Fania a,b, Ilaria Sogno c, Michele Vasso d, Enrica Torretta a,b, Roberta Leone a, Antonino Bruno c, Paolo Consonni c, Adriana Albini e, Cecilia Gelfi a,b,f (2015)
  A PSA-guided approach for a better diagnosis of prostatic adenocarcinoma based on MALDI profiling and peptide identification.
  in Clinica chimica acta (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Chiara Fania a,b, Ilaria Sogno c, Michele Vasso d, Enrica Torretta a,b, Roberta Leone a, Antonino Bruno c, Paolo Consonni c, Adriana Albini e, Cecilia Gelfi a,b,f (literal)

Pagina inizio

• 49 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 439 (literal)

Rivista

• Clinica chimica acta (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 42 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi Di Milano, Via F.lli Cervi 93, Segrate Milan 20090, Italy b. IRCCS Policlinico San Donato, Piazza Edmondo Malan, San Donato Milanese Milan 20097, Italy c. Istituto di Ricovero e Cura a Carattere Scientifico MultiMedica, via Fantoli 16/15, Milan 20138, Italy d. Istituto di Bioimmagini e Fisiologia Molecolare (IBFM)-CNR, C.da Pietrapollastra-Pisciotto, Cefalù Palermo 90015, Italy e. IRCCS Tecnologie Avanzate e Modelli Assistenziali in Oncologia - Arcispedale Santa Maria Nuova, Viale Umberto I 50, Reggio Emilia 42123, Italy f. Istituto di Bioimmagini e Fisiologia Molecolare (IBFM)-CNR, Via F.lli Cervi 93, Segrate, Milan 20090, Italy (literal)

Titolo

• A PSA-guided approach for a better diagnosis of prostatic adenocarcinoma based on MALDI profiling and peptide identification. (literal)

Abstract

• BACKGROUND: Prostate cancer (PCa) is the second cause of mortality in men worldwide. The prostate-specific antigen (PSA) test is routinely adopted in diagnosis; nevertheless more reliable biomarkers are continuously under investigation by monitoring the release of molecules into the bloodstream. The serum protein profiles appear to provide cancer-specific fingerprints that help to discriminate patients (especially with low PSA level) from controls, improving the performance of existing clinical tests. METHODS: Samples from healthy controls and PCa patients with low (<=4ng/mL) and high PSA (>4ng/mL) levels were analyzed by MALDI profiling, and by a multi fractionation approach coupled to ESI-MS for peaks identification. RESULTS: MALDI profiling achieved to detect 10 and 14 changed peaks (p-value <0.05), respectively, in PCa patients with low and high PSA versus controls. In particular, a peak identified as C3f fragment, resulted overexpressed in low PSA PCa patients. CONCLUSIONS: PSA test, coupled to MALDI profiling, is able to detect changes, specifically related to PCa, in low molecular weight protein range. Furthermore, for the first time in prostate cancer research, the identification and quantification of the small peptide C3f appears to be relevant for the detection of false negatives, providing an additive diagnostic power to PSA (p<0.01) and suggesting its use in clinical tests. (literal)

Prodotto di

• Proteomica differenziale di tessuti patologici e fluidi biologici per la comprensione della biologia dei sistemi (ME.P06.026.002) (Modulo)
• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR

• CECILIA GELFI (Unità di personale esterno)
• MICHELE VASSO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "A PSA-guided approach for a better diagnosis of prostatic adenocarcinoma based on MALDI profiling and peptide identification." (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Proteomica differenziale di tessuti patologici e fluidi biologici per la comprensione della biologia dei sistemi (ME.P06.026.002) (Modulo)

Autore CNR di

• MICHELE VASSO (Unità di personale interno)
• CECILIA GELFI (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Clinica chimica acta (Rivista)

Insieme di parole chiave di

• Keywords of "A PSA-guided approach for a better diagnosis of prostatic adenocarcinoma based on MALDI profiling and peptide identification." (Insieme di parole chiave)