GLP-1 and Glucose Tolerance After Sleeve Gastrectomy in Morbidly Obese Subjects With Type 2 Diabetes. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• GLP-1 and Glucose Tolerance After Sleeve Gastrectomy in Morbidly Obese Subjects With Type 2 Diabetes. (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.2337/db14-0357 (literal)

Alternative label

• Jimenez, A.; Mari, A.; Casamitjana, R.; Lacy, A.; Ferrannini, E.; Vidal, J. (2014)
  GLP-1 and Glucose Tolerance After Sleeve Gastrectomy in Morbidly Obese Subjects With Type 2 Diabetes.
  in Diabetes (N.Y.N.Y. : Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Jimenez, A.; Mari, A.; Casamitjana, R.; Lacy, A.; Ferrannini, E.; Vidal, J. (literal)

Pagina inizio

• 3372 (literal)

Pagina fine

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/24848069 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 63 (literal)

Rivista

• Diabetes (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 10 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1: Obesity Unit, Hospital Clinic Universitari, Barcelona, Spain / Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain; 2: Consiglio Nazionale delle Ricerche Institute of Biomedical Engineering, Padua, Italy; 3: Obesity Unit, Hospital Clinic Universitari, Barcelona, Spain / Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain / CIBERDEM, Barcelona, Spain; 4: Obesity Unit, Hospital Clinic Universitari, Barcelona, Spain / CIBERDEM, Barcelona, Spain; 5: Department of Clinical and Experimental Medicine, University of Pisa School of Medicine, Pisa, Italy 6: Obesity Unit, Hospital Clinic Universitari, Barcelona, Spain / Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain / CIBERDEM, Barcelona, Spain; (literal)

Titolo

• GLP-1 and Glucose Tolerance After Sleeve Gastrectomy in Morbidly Obese Subjects With Type 2 Diabetes. (literal)

Abstract

• Although GLP-1 has been suggested as a major factor for the marked improvement of glucose tolerance commonly seen after sleeve gastrectomy (SG), several observations challenge this hypothesis. To better understand the role of GLP-1 in the remission of type 2 diabetes mellitus (T2DM) long term after SG in humans, we conducted two separate cross-sectional studies: 1) the GLP-1 response to a standardized mixed liquid meal (SMLM) was compared in subjects with T2DM antedating SG but with different long-term (>2 years) T2DM outcomes (remission, relapse, or lack of remission) (study 1) and 2) the effect of GLP-1 receptor blockade with exendin (9-39) on glucose tolerance was examined in subjects with T2DM antedating surgery, who had undergone SG and presented with long-term T2DM remission (study 2). In study 1, we observed a comparable GLP-1 response to the SMLM regardless of the post-SG outcome of T2DM. In study 2, the blockade of GLP-1 action resulted in impaired insulin secretion but limited deterioration of glucose tolerance. Thus, our data suggest the enhanced GLP-1 secretion observed long term after SG is neither sufficient nor critical to maintain normal glucose tolerance in subjects with T2DM antedating the surgery. (literal)

Prodotto di

• Institute of biomedical engineering (ISIB) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)

Autore CNR

• ANDREA MARI (Unità di personale interno)

Incoming links:

Prodotto

• Institute of biomedical engineering (ISIB) (Istituto)
• Istituto di neuroscienze (IN) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)

Autore CNR di

• ANDREA MARI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Diabetes (Rivista)