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OTX1 expression in breast cancer is regulated by p53 (Articolo in rivista)

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OTX1 expression in breast cancer is regulated by p53 (Articolo in rivista) (literal)

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Terrinoni A.; Pagani I.S.; Zucchi I.; Chiaravalli A.M.; Serra V.; Rovera F.; Sirchia S.; Dionigi G.; Miozzo M.; Frattini A.; Ferrari A.; Capella C.; Pasquali F.; Curto F.L.; Albertini A.; Melino G.; Porta G. (2011)
OTX1 expression in breast cancer is regulated by p53
in Oncogene (Basingstoke, Online)
(literal)

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Terrinoni A.; Pagani I.S.; Zucchi I.; Chiaravalli A.M.; Serra V.; Rovera F.; Sirchia S.; Dionigi G.; Miozzo M.; Frattini A.; Ferrari A.; Capella C.; Pasquali F.; Curto F.L.; Albertini A.; Melino G.; Porta G. (literal)

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Biochemistry Laboratory, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy; Department of Experimental and Clinical Biomedical Sciences, Università dell'Insubria, via Dunant 5, Varese 21100, Italy; Institute of Biomedical Technologies, National Research Council, Milan, Italy; Department of Pathology, Ospedale di Circolo, Varese, Italy; Department of Surgical Sciences, University of Insubria, Varese, Italy; Department of Medicine, Surgery and Dentistry, Medical Genetics Unit, Universita' Degli Studi di Milano, Milano, Italy; Endocrine Surgery Research Center, Department of Surgical Sciences, University of Insubria, Varese, Italy; Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy; Department of Human Morphology, Anatomic Pathology Unit, University of Insubria, Varese, Italy; Medical Research Council, Hodgkin Building, Leicester University, Leicester, United Kingdom (literal)

Titolo

Abstract

The p53 transcription factor has a critical role in cell stress response and in tumor suppression. Wild-type p53 protein is a growth modulator and its inactivation is a critical event in malignant transformation. It has been recently demonstrated that wild-type p53 has developmental and differentiation functions. Indeed an over-expression of p53 in tumor cells induces asymmetrical division avoiding self-renewal of cancer stem cells (CSCs) and instead promoting their differentiation. In this study, 28 human breast carcinomas have been analyzed for expression of wild-type p53 and of a pool of non-clustered homeobox genes. We demonstrated that orthodenticle homolog 1 gene (OTX1) is transcribed in breast cancer. We established that the p53 protein directly induces OTX1 expression by acting on its promoter. OTX1 has been described as a critical molecule for axon refinement in the developing cerebral cortex of mice, and its activity in breast cancer suggests a synergistic function with p53 in CSC differentiation. Wild-type p53 may regulate cellular differentiation by an alternative pathway controlling OTX1 signaling only in breast cancer cells and not in physiological conditions. © 2011 Macmillan Publishers Limited All rights reserved. (literal)

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