http://www.cnr.it/ontology/cnr/individuo/prodotto/ID284558

Dyskinesia in Parkinson's disease: mechanisms and current non-pharmacological interventions (Articolo in rivista)

Type

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Dyskinesia in Parkinson's disease: mechanisms and current non-pharmacological interventions (Articolo in rivista) (literal)

Anno

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Alternative label

Heumann, Rolf; Moratalla, Rosario; Trinidad Herrero, Maria; Chakrabarty, Koushik; Drucker-Colin, Rene; Ruben Garcia-Montes, Jose; Simola, Nicola; Morelli, Micaela (2014)
Dyskinesia in Parkinson's disease: mechanisms and current non-pharmacological interventions
in Journal of neurochemistry
(literal)

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Heumann, Rolf; Moratalla, Rosario; Trinidad Herrero, Maria; Chakrabarty, Koushik; Drucker-Colin, Rene; Ruben Garcia-Montes, Jose; Simola, Nicola; Morelli, Micaela (literal)

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Ruhr University Bochum; Consejo Superior de Investigaciones Cientificas (CSIC); ISCIII; Universitat Jaume I; Universidad Nacional Autonoma de Mexico; University of Cagliari; University of Cagliari; Consiglio Nazionale delle Ricerche (CNR); University of Cagliari (literal)

Titolo

Dyskinesia in Parkinson's disease: mechanisms and current non-pharmacological interventions (literal)

Abstract

Dopamine replacement therapy in Parkinson's disease is associated with several unwanted effects, of which dyskinesia is the most disabling. The development of new therapeutic interventions to reduce the impact of dyskinesia in Parkinson's disease is therefore a priority need. This review summarizes the key molecular mechanisms that underlie dyskinesia. The role of dopamine receptors and their associated signaling mechanisms including dopamine-cAMP-regulated neuronal phosphoprotein, extracellular signal-regulated kinase, mammalian target of rapamycin, mitogen and stress-activated kinase-1 and Histone H3 are summarized, along with an evaluation of the role of cannabinoid and nicotinic acetylcholine receptors. The role of synaptic plasticity and animal behavioral results on dyskinesia are also evaluated. The most recent therapeutic advances to treat Parkinson's disease are discussed, with emphasis on the possibilities and limitations of non-pharmacological interventions such as physical activity, deep brain stimulation, transcranial magnetic field stimulation and cell replacement therapy. The review suggests new prospects for the management of Parkinson's disease-associated motor symptoms, especially the development of dyskinesia. (literal)

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