Disuse deterioration of human skeletal muscle challenged by resistive exercise superimposed with vibration: evidence from structural and proteomic analysis. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Disuse deterioration of human skeletal muscle challenged by resistive exercise superimposed with vibration: evidence from structural and proteomic analysis. (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1096/fj.14-252825 (literal)

Alternative label

• Michele Salanova,*,1,2 Cecilia Gelfi,?,§,,1,2 Manuela Moriggi,? Michele Vasso,§,¶ Agnese Viganò,? Luigi Minafra,¶ Gaetano Bonifacio,# Gudrun Schiffl,* Martina Gutsmann,* Dieter Felsenberg,+ Paolo Cerretelli,§ and Dieter Blottner* (2014)
  Disuse deterioration of human skeletal muscle challenged by resistive exercise superimposed with vibration: evidence from structural and proteomic analysis.
  in The FASEB journal
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Michele Salanova,*,1,2 Cecilia Gelfi,?,§,,1,2 Manuela Moriggi,? Michele Vasso,§,¶ Agnese Viganò,? Luigi Minafra,¶ Gaetano Bonifacio,# Gudrun Schiffl,* Martina Gutsmann,* Dieter Felsenberg,+ Paolo Cerretelli,§ and Dieter Blottner* (literal)

Pagina inizio

• 4748 (literal)

Pagina fine

• 4763 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 28 (literal)

Rivista

• ?The ?FASEB journal (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 11 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• *Center of Space Medicine Berlin, Neuromuscular Group, Institute of Anatomy, and + Center for Muscle and Bone Research (ZMK), Charité Universitätsmedizin Berlin, Berlin, Germany; ? Department of Biomedical Sciences for Health, University of Milan, Milan, Italy; § Consiglio Nazionale delle Ricerche (CNR), Institute of Bioimaging and Molecular Physiology, Segrate, Italy; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Donato, San Donato Milanese, Italy; ¶ Institute of Bioimaging and Molecular Physiology, CNR-Laboratorio di Tecnologie Oncologiche (LATO), Cefalù, Italy; and # Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland (literal)

Titolo

• Disuse deterioration of human skeletal muscle challenged by resistive exercise superimposed with vibration: evidence from structural and proteomic analysis. (literal)

Abstract

• In the present bed rest (BR) study, 23 volunteers were randomized into 3 subgroups: 60 d BR control (Ctr); BR with resistive exercise (RE; lower-limb load); and resistive vibration exercise (RVE; RE with superimposed vibration). The aim was to analyze by confocal and electron microscopy the effects of vibration on myofibril and filament integrity in soleus (Sol) and vastus lateralis (VL) muscle; differential proteomics of contractile, cytoskeletal, and costameric proteins (TN-C, ROCK1, and FAK); and expression of PGC1? and atrophy-related master genes MuRF1 and MuRF2. RVE (but not RE) preserved myofiber size and phenotype in Sol and VL by overexpressing MYBPC1 (42%, P<=0.01), WDR1 (39%, P<=0.01), sarcosin (84%, P<=0.01), and CKM (20%, P<=0.01) and prevented myofibrillar ultrastructural damage as detectable by MuRF1 expression. In Sol, cytoskeletal and contractile proteins were normalized by RVE, and TN-C increased (59%, P<=0.01); the latter also with RE (108%, P<=0.01). In VL, the outcomes of both RVE (acting on sarcosin and desmin) and RE (by way of troponinT-slow and MYL2) were similar. RVE appears to be a highly efficient countermeasure protocol against muscle atrophy and ultrastructural and molecular dysregulation induced by chronic disuse.-Salanova, M., Gelfi, C., Moriggi, M., Vasso, M., Viganò, A., Minafra, L., Bonifacio, G., Schiffl, G., Gutsmann, M., Felsenberg, D., Cerretelli, P., Blottner, D. Disuse deterioration of human skeletal muscle challenged by resistive exercise superimposed with vibration: evidence from structural and proteomic analysis. (literal)

Prodotto di

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Proteomica differenziale di tessuti patologici e fluidi biologici per la comprensione della biologia dei sistemi (ME.P06.026.002) (Modulo)

Autore CNR

• LUIGI MINAFRA (Unità di personale interno)
• CECILIA GELFI (Unità di personale esterno)
• MICHELE VASSO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Disuse deterioration of human skeletal muscle challenged by resistive exercise superimposed with vibration: evidence from structural and proteomic analysis." (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Proteomica differenziale di tessuti patologici e fluidi biologici per la comprensione della biologia dei sistemi (ME.P06.026.002) (Modulo)

Autore CNR di

• MICHELE VASSO (Unità di personale interno)
• LUIGI MINAFRA (Unità di personale interno)
• CECILIA GELFI (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• ?The ?FASEB journal (Rivista)

Insieme di parole chiave di

• Keywords of "Disuse deterioration of human skeletal muscle challenged by resistive exercise superimposed with vibration: evidence from structural and proteomic analysis." (Insieme di parole chiave)