Dyskinesia caused by ziconotide-baclofen combination in an adolescent affected by cerebral palsy (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Dyskinesia caused by ziconotide-baclofen combination in an adolescent affected by cerebral palsy (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1097/AAP.0000000000000054 (literal)

Alternative label

• Pozzi M.; Piccinini L.; Giordano F.; Carnovale C.; Perrone V.; Pellegrino P.; Antoniazzi S.; Turconi A.C.; Radice S.; Clementi E. (2014)
  Dyskinesia caused by ziconotide-baclofen combination in an adolescent affected by cerebral palsy
  in Regional anesthesia and pain medicine
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Pozzi M.; Piccinini L.; Giordano F.; Carnovale C.; Perrone V.; Pellegrino P.; Antoniazzi S.; Turconi A.C.; Radice S.; Clementi E. (literal)

Pagina inizio

• 172 (literal)

Pagina fine

• 173 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-84894415813&partnerID=q2rCbXpz (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 39 (literal)

Rivista

• Regional anesthesia and pain medicine (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Scientific Institute IRCCS Eugenio Medea, Lecco, Italy; AOU Anna Meyer Children's Hospital, Florence, Italy; Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, Università di Milano, Italy; IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Italy; Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, University of Milano, Via GB Grassi 74, 20157 Milano, Italy (literal)

Titolo

• Dyskinesia caused by ziconotide-baclofen combination in an adolescent affected by cerebral palsy (literal)

Abstract

• OBJECTIVE: To report on the first case of ziconotide-induced dyskinesia. Ziconotide, a synthetic peptide analogue of the ?-conotoxin MVIIA that blocks selectively N-type voltage-sensitive calcium channels, has been used in intrathecal administration for 30 years. Ziconotide is a drug of choice for chronic pain because of its efficacy and flexibility because it can substitute or complement other intrathecal therapies including morphine or baclofen. Whereas substantial information is available regarding its efficacy, systematic data regarding the safety of ziconotide remain scant. The adverse reactions to ziconotide described so far regard only the coordination and execution of intentional movements. CASE REPORT: A 15-year-old male patient developed dyskinesia affecting the head and upper limbs 2 days after administration of ziconotide as an add-on therapy to an established regimen of treatment with baclofen. The strict temporal relationship between ziconotide administration and dyskinesia, together with the absence of any other clinical alteration, led to the hypothesis of a possible adverse drug reaction. Ziconotide was thus withdrawn, and the symptoms disappeared within 2 days. CONCLUSIONS: An analysis of the signaling pathways of baclofen and ziconotide revealed a possible drug interaction that allowed ziconotide to trigger dyskinesia. Copyright © 2014 by American Society of Regional Anesthesia and Pain. (literal)

Prodotto di

• Institute of neuroscience (IN) (Istituto)
• Modelli in vitro ed in vivo per lo studio di patologie (ME.P02.007.002) (Modulo)

Autore CNR

• Emilio Clementi (Unità di personale esterno)

Incoming links:

Prodotto

• Institute of neuroscience (IN) (Istituto)
• Modelli in vitro ed in vivo per lo studio di patologie (ME.P02.007.002) (Modulo)

Autore CNR di

• Emilio Clementi (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Regional anesthesia and pain medicine (Rivista)