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Thermophiles as potential source of novel endotoxin antagonists: The full structure and bioactivity of thelipo-oligosaccharide from thermomonas hydrothermalis (Articolo in rivista)

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Thermophiles as potential source of novel endotoxin antagonists: The full structure and bioactivity of thelipo-oligosaccharide from thermomonas hydrothermalis (Articolo in rivista) (literal)

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Di Lorenzo F.; Paciello I.; Fazio L.L.; Albuquerque L.; Sturiale L.; da Costa M.S.; Lanzetta R.; Parrilli M.; Garozzo D.; Bernardini M.L.; Silipo D.A.; Molinaro A. (2014)
Thermophiles as potential source of novel endotoxin antagonists: The full structure and bioactivity of thelipo-oligosaccharide from thermomonas hydrothermalis
in ChemBioChem (Internet); Wiley-VCH Verlag, GmbH, Weinheim (Germania)
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Di Lorenzo F.; Paciello I.; Fazio L.L.; Albuquerque L.; Sturiale L.; da Costa M.S.; Lanzetta R.; Parrilli M.; Garozzo D.; Bernardini M.L.; Silipo D.A.; Molinaro A. (literal)

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Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario Monte S.Angelo, Via Cintia 4, 80126 Napoli (Italy); Dipartimento di Biologia e Biotecnologie C. Darwin, Sapienza-Università di Roma, Piazzale Aldo Moro 5, 00185 Roma (Italy); Center for Neuroscience and Cell Biology and Department of Life Sciences, University of Coimbra, 3001-401 Coimbra (Portugal); Istituto di Chimica e Tecnologia dei Polimeri-ICTP-CNR, Via P. Gaifami 18, 95126 Catania (Italy); Istituto Pasteur-Fondazione Cenci Bolognetti, Piazzale Aldo Moro 5, 00185 Roma (Italia), Sapienza-Università di Roma, 00185 Roma (Italy) (literal)

Titolo

Thermophiles as potential source of novel endotoxin antagonists: The full structure and bioactivity of thelipo-oligosaccharide from thermomonas hydrothermalis (literal)

Abstract

Thermomonas hydrothermalis is a Gram-negative thermophilic bacterium that is able to live at 50°C. This ability is attributed to chemical modifications, involving those to bacterial cell-wall components, such as proteins and (glyco)lipids. As the main component of the outer membrane of Gram-negative bacteria, lipopolysaccharides (LPSs) are exposed to the environment, thus they can undergo structural chemical changes to allow thermophilic bacteria to live at their optimal growth temperature. Furthermore, as one of the major target of the eukaryotic innate immune system, LPS elicits host immune response in a structure-dependent mode; thus the uncommon chemical features of thermophilic bacterial LPSs might exert a different biological action on the innate immune system-an antagonistic effect, as shown in studies of LPS structure-activity relationship in the ongoing research into antagonist LPS candidates. Here, we report the complete structural and biological activity analysis of the lipo-oligosaccharide isolated from Thermomonas hydrothermalis, achieved by a multidisciplinary approach (chemical analysis, NMR, MALDI MS and cellular immunology). We demonstrate a tricky and interesting structure combined with a very interesting effect on human innate immunity. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. (literal)

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