Fluorescent silver(i) and gold(i)-N-heterocyclic carbene complexes with cytotoxic properties: Mechanistic insights (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Fluorescent silver(i) and gold(i)-N-heterocyclic carbene complexes with cytotoxic properties: Mechanistic insights (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1039/c3mt20260g (literal)

Alternative label

• Citta A.; Schuh E.; Mohr F.; Folda A.; Massimino M.L.; Bindoli A.; Casini A.; Rigobello M.P. (2013)
  Fluorescent silver(i) and gold(i)-N-heterocyclic carbene complexes with cytotoxic properties: Mechanistic insights
  in Metallomics (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Citta A.; Schuh E.; Mohr F.; Folda A.; Massimino M.L.; Bindoli A.; Casini A.; Rigobello M.P. (literal)

Pagina inizio

• 1006 (literal)

Pagina fine

• 1015 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-84880875664&partnerID=q2rCbXpz (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 5 (literal)

Rivista

• Metallomics (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 8 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Dipartimento di Scienze Biomediche, Università di Padova, Viale G. Colombo 3, 35131 Padova, Italy; Fachbereich C, Anorganische Chemie, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany; Istituto di Neuroscienze (CNR), Sezione di Padova, C/o Dipartimento di Scienze Biomediche, Viale G. Colombo 3, 35131 Padova, Italy; Pharmacokinetics, Toxicology and Targeting, Research Institute of Pharmacy, University of Groningen Antonius, Deusinglaan 1, 9713 AV Groningen, Netherlands (literal)

Titolo

• Fluorescent silver(i) and gold(i)-N-heterocyclic carbene complexes with cytotoxic properties: Mechanistic insights (literal)

Abstract

• Silver(i) and gold(i)-N-heterocyclic carbene (NHC) complexes bearing a fluorescent anthracenyl ligand were examined for cytotoxicity in normal and tumor cells. The silver(i) complex exhibits greater cytotoxicity in tumor cells compared with normal cells. Notably, in cell extracts, this complex determines a more pronounced inhibition of thioredoxin reductase (TrxR), but it is ineffective towards glutathione reductase (GR). Both gold and silver complexes lead to oxidation of the thioredoxin system, the silver(i) derivative being particularly effective. In addition, the dimerization of peroxiredoxin 3 (Prx3) was also observed, demonstrating the ability of these compounds to reach the mitochondrial target. The fluorescence microscopy visualization of the subcellular distribution of the complexes shows a larger diffusion of these molecules in tumor cells with respect to normal cells. © 2013 The Royal Society of Chemistry. (literal)

Prodotto di

• Institute of neuroscience (IN) (Istituto)
• Neurobiologia e Neuropatologia (ME.P02.005.001) (Modulo)

Autore CNR

• MARIA LINA MASSIMINO (Persona)

Incoming links:

Prodotto

• Institute of neuroscience (IN) (Istituto)
• Neurobiologia e Neuropatologia (ME.P02.005.001) (Modulo)

Autore CNR di

• MARIA LINA MASSIMINO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Metallomics (Rivista)