http://www.cnr.it/ontology/cnr/individuo/prodotto/ID283034

Kinase CK2 inhibition: An update (Articolo in rivista)

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Cozza G.; Pinna L.A.; Moro S. (2013)
Kinase CK2 inhibition: An update
in Current medicinal chemistry
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Department of Biomedical Sciences, University of Padova, Padova 35121, Italy; CNR, Institute of Neuroscience, University of Padova, Padova 35121, Italy; Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo, 5-35131 Padova, Italy (literal)

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Abstract

Protein kinase CK2 (Casein Kinase 2) is an essential, ubiquitous and highly pleiotropic protein kinase, implicated in several human diseases. In the last decade, several inhibitors of CK2, have been discovered and characterized to be ATP-competitive compounds. However, only one of them, CX-4945, has recently completed Phase I clinical trial as potential anticancer drug. In this review, we report all chemical classes of CK2 inhibitors available in literature, focusing our attention on conventional ATP-competitive and on non ATP-competitive inhibitors, which could represent a new frontier in CK2 inhibition and, consequently, a promising field of study in discovering new drug candidates. © 2013 Bentham Science Publishers. (literal)

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