Mantra 2.0: An online collaborative resource for drug mode of action and repurposing by network analysis (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Mantra 2.0: An online collaborative resource for drug mode of action and repurposing by network analysis (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1093/bioinformatics/btu058 (literal)

Alternative label

• Carrella D.; Napolitano F.; Rispoli R.; Miglietta M.; Carissimo A.; Cutillo L.; Sirci F.; Gregoretti F.; Di Bernardo D. (2014)
  Mantra 2.0: An online collaborative resource for drug mode of action and repurposing by network analysis
  in Bioinformatics (Oxf., Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Carrella D.; Napolitano F.; Rispoli R.; Miglietta M.; Carissimo A.; Cutillo L.; Sirci F.; Gregoretti F.; Di Bernardo D. (literal)

Pagina inizio

• 1787 (literal)

Pagina fine

• 1788 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-84902007424&partnerID=q2rCbXpz (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 30 (literal)

Rivista

• Bioinformatics (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 12 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Telethon Institute of Genetics and Medicine, Via P. Castellino 111, 80131 Naples, Italy; Interactive SRL, Via Fratelli Bisogno 5, 83100 Avellino, Italy; Dip. di Studi Aziendali e Quantitativi, Università Degli Studi di Napoli Parthenope, Via Generale Parisi 13, 80132 Naples, Italy; Institute for High-Performance Computing - ICAR - CNR, Via P. Castellino 111, 80131 Naples, Italy; Department of Electrical Engineering and Information Technology, University of Naples Federico II, Via Claudio 21, 80125 Naples, Italy (literal)

Titolo

• Mantra 2.0: An online collaborative resource for drug mode of action and repurposing by network analysis (literal)

Abstract

• Elucidation of molecular targets of a compound [mode of action (MoA)- and its off-targets is a crucial step in drug development. We developed an online collaborative resource (MANTRA 2.0) that supports this process by exploiting similarities between drug-induced transcriptional profiles. Drugs are organized in a network of nodes (drugs) and edges (similarities) highlighting 'communities' of drugs sharing a similar MoA. A user can upload gene expression profiles before and after drug treatment in one or multiple cell types. An automated processing pipeline transforms the gene expression profiles into a unique drug 'node' embedded in the drug-network. Visual inspection of the neighbouring drugs and communities helps in revealing its MoA and to suggest new applications of known drugs (drug repurposing). MANTRA 2.0 allows storing and sharing user-generated network nodes, thus making MANTRA 2.0 a collaborative ever-growing resource. © 2014 The Author. Published by Oxford University Press. All rights reserved. (literal)

Prodotto di

• Institute for high performance computing and networking (ICAR) (Istituto)
• Metodi, algoritmi e librerie scientifiche innovative per l'analisi di dati genomici e di immagini cellulari (ICT.P09.002.002) (Modulo)

Autore CNR

• FRANCESCO GREGORETTI (Persona)

Incoming links:

Prodotto

• Institute for high performance computing and networking (ICAR) (Istituto)
• Metodi, algoritmi e librerie scientifiche innovative per l'analisi di dati genomici e di immagini cellulari (ICT.P09.002.002) (Modulo)

Autore CNR di

• FRANCESCO GREGORETTI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Bioinformatics (Rivista)