A bioartificial renal tubule device embedding human renal stem/progenitor cells (Articolo in rivista)

Type
Label
  • A bioartificial renal tubule device embedding human renal stem/progenitor cells (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1371/journal.pone.0087496 (literal)
Alternative label
  • Sciancalepore A.G.[ 1 ] ; Sallustio F.[ 2,3,4 ]; Girardo S.[ 5 ] ; Passione L.G.[ 1,5,6 ]; Camposeo A.[ 1,5 ] ; Mele E.[ 1 ]; Lorenzo M.D.[ 5 ]; Costantino V.[ 2 ] ; Schena F.P.[ 2,3 ] ; Pisignano D.[ 1,5,6 ] (2014)
    A bioartificial renal tubule device embedding human renal stem/progenitor cells
    in PloS one
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Sciancalepore A.G.[ 1 ] ; Sallustio F.[ 2,3,4 ]; Girardo S.[ 5 ] ; Passione L.G.[ 1,5,6 ]; Camposeo A.[ 1,5 ] ; Mele E.[ 1 ]; Lorenzo M.D.[ 5 ]; Costantino V.[ 2 ] ; Schena F.P.[ 2,3 ] ; Pisignano D.[ 1,5,6 ] (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84898452859&partnerID=q2rCbXpz (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 9 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 1 (literal)
Note
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • [ 1 ] Ist Italiano Tecnol, Ctr Biomol Nanotechnol, Arnesano, Italy [ 2 ] Univ Bari, Dept Emergency & Organ Transplantat, Nephrol Dialysis & Transplantat Unit, Bari, Italy [ 3 ] Ctr Addestramento Ric Sci Oncol CARSO Consortium, Valenzano, Italy [ 4 ] Univ Salento, Dept Sci Biol & Environm Sci & Technol, Lecce, Italy [ 5 ] CNR, Ist Nanosci, Natl Nanotechnol Lab, Lecce, Italy [ 6 ] Univ Salento, Dipartimento Matemat & Fis Ennio De Giorgi, Lecce, Italy (literal)
Titolo
  • A bioartificial renal tubule device embedding human renal stem/progenitor cells (literal)
Abstract
  • We present a bio-inspired renal microdevice that resembles the in vivo structure of a kidney proximal tubule. For the first time, a population of tubular adult renal stem/progenitor cells (ARPCs) was embedded into a microsystem to create a bioengineered renal tubule. These cells have both multipotent differentiation abilities and an extraordinary capacity for injured renal cell regeneration. Therefore, ARPCs may be considered a promising tool for promoting regenerative processes in the kidney to treat acute and chronic renal injury. Here ARPCs were grown to confluence and exposed to a laminar fluid shear stress into the chip, in order to induce a functional cell polarization. Exposing ARPCs to fluid shear stress in the chip led the aquaporin-2 transporter to localize at their apical region and the Na+K+ ATPase pump at their basolateral portion, in contrast to statically cultured ARPCs. A recovery of urea and creatinine of (20 +/- 5)% and (13 +/- 5)%, respectively, was obtained by the device. The microengineered biochip here-proposed might be an innovative \"lab-on-a-chip\" platform to investigate in vitro ARPCs behaviour or to test drugs for therapeutic and toxicological responses. (literal)
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