Manganese overload affects p38 MAPK phosphorylation and metalloproteinase activity during sea urchin embryonic development (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Manganese overload affects p38 MAPK phosphorylation and metalloproteinase activity during sea urchin embryonic development (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.marenvres.2013.08.004 (literal)

Alternative label

• Pinsino A.; Roccheri M.C.; Matranga V. (2014)
  Manganese overload affects p38 MAPK phosphorylation and metalloproteinase activity during sea urchin embryonic development
  in Marine environmental research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Pinsino A.; Roccheri M.C.; Matranga V. (literal)

Pagina inizio

• 64 (literal)

Pagina fine

• 69 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.sciencedirect.com/science/article/pii/S0141113613001293 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 93 (literal)

Rivista

• Marine environmental research (Rivista)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), Università di Palermo, Italy; Istituto di Biomedicina e Immunologia Molecolare Alberto Monroy, Consiglio Nazionale delle Ricerche, Palermo, Italy (literal)

Titolo

• Manganese overload affects p38 MAPK phosphorylation and metalloproteinase activity during sea urchin embryonic development (literal)

Abstract

• In the marine environment, manganese represents a potential emerging contaminant, resulting from an increased production of manganese-containing compounds. In earlier reports we found that the exposure of Paracentrotus lividus sea urchin embryos to manganese produced phenotypes with no skeleton. In addition, manganese interfered with calcium uptake, perturbed extracellular signal-regulated kinase (ERK) signaling, affected the expression of skeletogenic genes, and caused an increase of the hsc70 and hsc60 protein levels. Here, we extended our studies focusing on the temporal activation of the p38 mitogen-activated protein kinase (p38 MAPK) and the proteolytic activity of metalloproteinases (MMPs). We found that manganese affects the stage-dependent dynamics of p38 MAPK activation and inhibits the total gelatin-auto-cleaving activity of MMPs, with the exclusion of the 90-85kDa and 68-58kDa MMPs, whose levels remain high all throughout development. Our findings correlate, for the first time to our knowledge, an altered activation pattern of the p38 MAPK with an aberrant MMP proteolytic activity in the sea urchin embryo. © 2013 Elsevier Ltd. (literal)

Prodotto di

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Stress Cellulare ed Ambiente (SV.P17.008.003) (Modulo)

Autore CNR

• ANNALISA PINSINO (Persona)
• VALERIA MATRANGA (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Manganese overload affects p38 MAPK phosphorylation and metalloproteinase activity during sea urchin embryonic development" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• VALERIA MATRANGA (Unità di personale interno)
• ANNALISA PINSINO (Persona)

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Stress Cellulare ed Ambiente (SV.P17.008.003) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Marine environmental research (Rivista)

Insieme di parole chiave di

• Keywords of "Manganese overload affects p38 MAPK phosphorylation and metalloproteinase activity during sea urchin embryonic development" (Insieme di parole chiave)