The \"second wind\" in McArdle's disease patients during a second bout of constant work rate submaximal exercise (Articolo in rivista)

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Label
  • The \"second wind\" in McArdle's disease patients during a second bout of constant work rate submaximal exercise (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1152/japplphysiol.01063.2013 (literal)
Alternative label
  • Simone Porcelli 1; Mauro Marzorati 1; Michele Belletti 2; Giuseppe Bellistri 1; Lucia Morandi 3; and Bruno Grassi 4. (2014)
    The "second wind" in McArdle's disease patients during a second bout of constant work rate submaximal exercise
    in Journal of applied physiology (1985 Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Simone Porcelli 1; Mauro Marzorati 1; Michele Belletti 2; Giuseppe Bellistri 1; Lucia Morandi 3; and Bruno Grassi 4. (literal)
Pagina inizio
  • 1230 (literal)
Pagina fine
  • 1237 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • Pubblicato on-line: 20 Marzo 2014 (literal)
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  • 116 (literal)
Rivista
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  • 9 (literal)
Note
  • PubMe (literal)
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  • 1. National Research Council 2. Universita' degli Studi di Milano 3. IRCCS Istituto Neurologico 4. Università degli Studi di Udine (literal)
Titolo
  • The \"second wind\" in McArdle's disease patients during a second bout of constant work rate submaximal exercise (literal)
Abstract
  • Patients with McArdle's disease (McA) typically show the \"second wind\" phenomenon, a sudden decrease in heart rate (HR) and an improved exercise tolerance occurring after a few minutes of exercise. In the present study we investigated whether in McA a first bout of exercise determines a second wind during a second bout, separated by the first by a few minutes of recovery. Eight McA (44±4 years) and a control group of 6 mitochondrial myopathy patients (MM) (51±6 years) performed two repetitions (CWR1 and CWR2) of 6-min constant work rate exercise (~50% of peak work rate) separated by 6-min (SHORT) or 18-min (LONG) recovery. Pulmonary O2 uptake (VO2), HR, cardiac output (Q), rates of perceived exertion (RPE), vastus lateralis oxygenation (?[deoxy(Hb+Mb)], by near-infrared spectroscopy) were determined. In McA VO2 (0.86±0.2 vs. 0.95±0.1 L.min-1), HR (113±10 vs. 150±13 b.min-1), Q (11.6±0.6 vs. 15.0±0.8 L.min-1), RPE (11±2 vs. 14±3) were lower, whereas ?[deoxy(Hb+Mb)] was higher (14.7±2.3 % vs. -0.1±4.6 %) in CWR2-SHORT vs. CWR1; the \"overshoot\" of ?[deoxy(Hb+Mb)] and the \"slow component\" of VO2 kinetics disappeared in CWR2-SHORT. No differences (vs. CWR1) were observed in McA during CWR2-LONG, or in MM during both CWR2-SHORT and -LONG. A second wind phenomenon was observed in McA during the second of two consecutive 6-min constant-work rate submaximal exercises. The second wind was associated with changes of physiological variables suggesting an enhanced skeletal muscle oxidative metabolism. The second wind was not described after a longer (18-min) recovery period. (literal)
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