Template induced nucleation of isonicotinamide polymorphs (Articolo in rivista)

Type
Label
  • Template induced nucleation of isonicotinamide polymorphs (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/cg401605m (literal)
Alternative label
  • Antonella Caridi, Samir A. Kulkarni, Gianluca Di Profio, Efrem Curcio, and Joop H. ter Horst (2014)
    Template induced nucleation of isonicotinamide polymorphs
    in Crystal growth & design; ACS, American chemical society, Washington, DC (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Antonella Caridi, Samir A. Kulkarni, Gianluca Di Profio, Efrem Curcio, and Joop H. ter Horst (literal)
Pagina inizio
  • 1135 (literal)
Pagina fine
  • 1141 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 14 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 3 (literal)
Note
  • Scopus (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Chemical Engineering and Materials Department, University of Calabria, Via P. Bucci Cubo 44/A, 87036 Rende, Italy Intensified Reaction & Separation Systems, Process & Energy Department, Delft University of Technology, Leeghwaterstraat 44, 2628 CA Delft, The Netherlands Institute on Membrane Technology (ITM-CNR), National Research Council of Italy, Via P. Bucci Cubo 17/C, 87036, Rende, Italy (literal)
Titolo
  • Template induced nucleation of isonicotinamide polymorphs (literal)
Abstract
  • By studying the potential of different heterogeneous templates to stimulate heterogeneous nucleation, this work aims to enhance the current knowledge of heterogeneous nucleation mechanisms and to obtain improved control of polymorphic selectivity in solution crystallization. The possibility of inducing nucleation of different isonicotinamide (INA) polymorphs by using heterogeneous templates, exhibiting porous and regular surfaces structures in the nanometer range, such as synthetic zeolite ZSM-5, mesoporous aluminosilicate MCM-41, and TiO2 in both rutile and anatase phase, was investigated by monitoring in real-time the course of the crystallization process. Experiments demonstrated that all used templates were effective in reducing induction time, thus being successful in enhancing the nucleation rate of INA. Furthermore, the ability of the TiO2 template in anatase form to induce the formation of a mixture of metastable forms I and III, thus diverting the expected course of polymorph crystallization due to INA self-association in ethanol, was demonstrated, providing an additional tool to achieve polymorphic selectivity in solution crystallization. (literal)
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