A Survey of FDG- and Amyloid-PET Imaging in Dementia and GRADE Analysis (Articolo in rivista)

Type
Label
  • A Survey of FDG- and Amyloid-PET Imaging in Dementia and GRADE Analysis (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1155/2014/785039 (literal)
Alternative label
  • Daniela Perani 1; Orazio Schillaci 2; Alessandro Padovani 3; Flavio Mariano Nobili 4; Leonardo Iaccarino 1; Pasquale Anthony Della Rosa 5; Giovanni Frisoni 6; Carlo Caltagirone 7. (2014)
    A Survey of FDG- and Amyloid-PET Imaging in Dementia and GRADE Analysis
    in BioMed Research International
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Daniela Perani 1; Orazio Schillaci 2; Alessandro Padovani 3; Flavio Mariano Nobili 4; Leonardo Iaccarino 1; Pasquale Anthony Della Rosa 5; Giovanni Frisoni 6; Carlo Caltagirone 7. (literal)
Pagina inizio
  • ID-785039, (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://dx.doi.org/10.1155/2014/785039 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 2014 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. Nuclear Medicine Department, Vita-Salute San Raffaele University, San Raffaele Hospital and Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy. 2. Nuclear Medicine Department, University of Rome \"Tor Vergata\" and IRCCS Neuromed, Pozzilli, Italy. 3. Department of Medical and Experimental Sciences, Unit of Neurology, Brescia University, Brescia, Italy. 4. Department of Neuroscience Ophthalmology and Genetics, University of Genoa, Genoa, Italy. 5. IBFM-CNR, Via F.lli Cervi 93, Segrate (MI) Italy. 6. IRCCS Centro San Giovanni di Dio Fatebenefratelli, and Memory Clinic and LANVIE, Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneve, Switzerland. 7. University of Rome Tor Vergata and IRCSS S. Lucia, Rome, Italy. (literal)
Titolo
  • A Survey of FDG- and Amyloid-PET Imaging in Dementia and GRADE Analysis (literal)
Abstract
  • PET based tools can improve the early diagnosis of Alzheimer's disease (AD) and differential diagnosis of dementia. The importance of identifying individuals at risk of developing dementia among people with subjective cognitive complaints or mild cognitive impairment has clinical, social, and therapeutic implications. Within the two major classes of AD biomarkers currently identified, that is, markers of pathology and neurodegeneration, amyloid- and FDG-PET imaging represent decisive tools for their measurement. As a consequence, the PET tools have been recognized to be of crucial value in the recent guidelines for the early diagnosis of AD and other dementia conditions. The references based recommendations, however, include large PET imaging literature based on visual methods that greatly reduces sensitivity and specificity and lacks a clear cut-off between normal and pathological findings. PET imaging can be assessed using parametric or voxel-wise analyses by comparing the subject's scan with a normative data set, significantly increasing the diagnostic accuracy. This paper is a survey of the relevant literature on FDG and amyloid-PET imaging aimed at providing the value of quantification for the early and differential diagnosis of AD. This allowed a meta-analysis and GRADE analysis revealing high values for PET imaging that might be useful in considering recommendations. (literal)
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