The beta-Subunit of Cholera Toxin has a High Affinity for Ganglioside GM1 Embedded into Solid Supported Lipid Membranes with a Lipid Raft-Like Composition (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• The beta-Subunit of Cholera Toxin has a High Affinity for Ganglioside GM1 Embedded into Solid Supported Lipid Membranes with a Lipid Raft-Like Composition (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s11745-013-3845-8 (literal)

Alternative label

• G. Margheri (1); R. D'Agostino (2); S. Trigari (1); S. Sottini (1); M. Del Rosso (2) (2014)
  The beta-Subunit of Cholera Toxin has a High Affinity for Ganglioside GM1 Embedded into Solid Supported Lipid Membranes with a Lipid Raft-Like Composition
  in Lipids
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• G. Margheri (1); R. D'Agostino (2); S. Trigari (1); S. Sottini (1); M. Del Rosso (2) (literal)

Pagina inizio

• 203 (literal)

Pagina fine

• 206 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://link.springer.com/article/10.1007%2Fs11745-013-3845-8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 49 (literal)

Rivista

• Lipids (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• (1). Institute for Complex Systems, National Research Council, Via Madonna del Piano 10, 50019, Sesto Fiorentino, Florence, Italy (2). Department of Pathology and Experimental Oncology, University of Florence, Viale G.B. Morgagni 50, 50134, Florence, Italy (literal)

Titolo

• The beta-Subunit of Cholera Toxin has a High Affinity for Ganglioside GM1 Embedded into Solid Supported Lipid Membranes with a Lipid Raft-Like Composition (literal)

Abstract

• In this communication, we report on the fabrication of GM1-rich solid-supported bilayer lipid membranes (ssBLM) made of sphingomyelin and cholesterol, the main components of lipid rafts, which are the physiological hosting microenvironment of GM1 on the cell membrane. The functionality of the ganglioside has been checked by measuring the apparent dissociation constant K D of the complex formed by the ?-subunit of the cholera toxin and GM1. The value found deviates less than one order of magnitude from that measured for in vivo cells, indicating the potential of these ssBLM as optimized in vitro biomimetic platforms. (literal)

Prodotto di

• comportamento dinamico di sistemi complessi (MD.P02.017.001) (Modulo)

Autore CNR

• SILVANA TRIGARI (Persona)
• STEFANO SOTTINI (Unità di personale esterno)
• GIANCARLO MARGHERI (Unità di personale interno)

Incoming links:

Autore CNR di

• SILVANA TRIGARI (Persona)
• GIANCARLO MARGHERI (Unità di personale interno)
• STEFANO SOTTINI (Unità di personale esterno)

Prodotto

• comportamento dinamico di sistemi complessi (MD.P02.017.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Lipids (Rivista)