Localization of Magic-F1 Transgene, Involved in Muscular Hypertrophy, during Early Myogenesis. (Articolo in rivista)

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  • Localization of Magic-F1 Transgene, Involved in Muscular Hypertrophy, during Early Myogenesis. (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1155/2011/492075 (literal)
Alternative label
  • Ronzoni F, Bongio M, Conte S, Vercesi L, Cassano M, Tribioli C, Galli D, Bellazzi R, Magenes G, Cusella De Angelis MG, Sampaolesi M. (2011)
    Localization of Magic-F1 Transgene, Involved in Muscular Hypertrophy, during Early Myogenesis.
    in Journal of Biomedicine and Biotechnology (Print); Hindawi Publishing Corporation, New York (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Ronzoni F, Bongio M, Conte S, Vercesi L, Cassano M, Tribioli C, Galli D, Bellazzi R, Magenes G, Cusella De Angelis MG, Sampaolesi M. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.hindawi.com/journals/jbb/2011/492075/ (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 2011 (literal)
Rivista
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  • In press (literal)
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  • 9 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 492075 (literal)
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  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Human Anatomy Section, University of Pavia, Via Forlanini 8, 27100 Pavia, Italy; Center for Tissue Engineering (CIT), University of Pavia, 27100 Pavia, Italy; Translational Cardiomyology (SCIL), Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium; Institute of Molecular Genetics, CNR, 27100 Pavia, Italy; Stem Cell Research Institute, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium (literal)
Titolo
  • Localization of Magic-F1 Transgene, Involved in Muscular Hypertrophy, during Early Myogenesis. (literal)
Abstract
  • We recently showed that Magic-F1 (Met-activating genetically improved chimeric factor 1), a human recombinant protein derived from hepatocyte growth factor/scatter factor (HGF/SF) induces muscle cell hypertrophy but not progenitor cell proliferation, both in vitro and in vivo. Here, we examined the temporal and spatial expression pattern of Magic-F1 in comparison with Pax3 (paired box gene 3) transcription factor during embryogenesis. Ranging from 9.5 to 17.5 dpc (days post coitum) mouse embryos were analyzed by in situ hybridization using whole mounts during early stages of development (9.5–10.5–11.5 dpc) and cryostat sections for later stages (11.5–13.5–15.5–17.5 dpc). We found that Magic-F1 is expressed in developing organs and tissues of mesenchymal origin, where Pax3 signal appears to be downregulated respect to the wt embryos. These data suggest that Magic-F1 could be responsible of muscular hypertrophy, cooperating with Pax3 signal pathway in skeletal muscle precursor cells. (literal)
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