http://www.cnr.it/ontology/cnr/individuo/prodotto/ID27842

Are myocardial infarction-associated single nucleotide polymorphisms associated with ischemic stroke? (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Are myocardial infarction-associated single nucleotide polymorphisms associated with ischemic stroke? (Articolo in rivista) (literal)

Anno

2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1161/STROKEAHA.111.632075 (literal)

Alternative label

Cheng YC, Anderson CD, Bione S, Keene K, Maguire JM, Nalls M, Rasheed A, Zeginigg M, Attia J, Baker R, Barlera S, Biffi A, Bookman E, Brott TG, Brown RD Jr, Chen F, Chen WM, Ciusani E, Cole JW, Cortellini L, Danesh J, Doheny K, Ferrucci L, Grazia Franzosi M, Frossard P, Furie KL, Golledge J, Hankey GJ,Hernandez D, Holliday EG, Hsu FC, Jannes J, Kamal A, Khan MS, Kittner SJ, Koblar SA, Lewis M, Lincz L, Lisa A, Matarin M, Moscato P, Mychaleckyj JC, Parati EA, Parolo S, Pugh E, Rost NS, Schallert M, Schmidt H, Scott RJ, Sturm JW, Yadav S, Zaidi M, Boncoraglio GB, Levi CR, Meschia JF, Rosand J, Sale M,Saleheen D, Schmidt R, Sharma P, Worrall B, Mitchell BD, GARNET Collaborative Research Group, GENEVA Consortium, on behalf of the International Stroke Genetics Consortium. (2012)
Are myocardial infarction-associated single nucleotide polymorphisms associated with ischemic stroke?
in Stroke; AHA, American heart association, Dallas, Tx. (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Cheng YC, Anderson CD, Bione S, Keene K, Maguire JM, Nalls M, Rasheed A, Zeginigg M, Attia J, Baker R, Barlera S, Biffi A, Bookman E, Brott TG, Brown RD Jr, Chen F, Chen WM, Ciusani E, Cole JW, Cortellini L, Danesh J, Doheny K, Ferrucci L, Grazia Franzosi M, Frossard P, Furie KL, Golledge J, Hankey GJ,Hernandez D, Holliday EG, Hsu FC, Jannes J, Kamal A, Khan MS, Kittner SJ, Koblar SA, Lewis M, Lincz L, Lisa A, Matarin M, Moscato P, Mychaleckyj JC, Parati EA, Parolo S, Pugh E, Rost NS, Schallert M, Schmidt H, Scott RJ, Sturm JW, Yadav S, Zaidi M, Boncoraglio GB, Levi CR, Meschia JF, Rosand J, Sale M,Saleheen D, Schmidt R, Sharma P, Worrall B, Mitchell BD, GARNET Collaborative Research Group, GENEVA Consortium, on behalf of the International Stroke Genetics Consortium. (literal)

Pagina inizio

980 (literal)

Pagina fine

986 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://stroke.ahajournals.org/content/43/4/980.abstract (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

43 (literal)

Rivista

Stroke (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

In press (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

4 (literal)

Note

ISI Web of Science (WOS) (literal)
PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Department of Medicine, University of Maryland, Baltimore, MD USA; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA; Institute of Molecular Genetics, National Research Council, Pavia, Italy ; Department of Medicine, University of Virginia, VA, USA; Center for Public Health Genomics, University of Virginia, VA, USA; Hunter Medical Research Institute (HMRI), University of Newcastle, Australia; School of Nursing and Midwifery, University of Newcastle, Australia; Laboratory of Neurogenetics, National Institute of Aging, National Institute of Health, Bethesda, MD, USA; Center for Non-Communicable Diseases, Karachi, Pakistan, Department of Neurology and Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria; Centre for Thrombosis and Haemophilia, Murdoch University, Australia; Department of Haematology, Royal Perth Hospital, Australia; Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy; National Human Genome Research Institute, National Institutes of Health, Rockville, MD, USA; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA; Department of Neurology, Mayo Clinic, Rochester, MN, USA; Department of Public Health Sciences, University of Virginia, VA, USA; Fondazione IRCCS Istituto Neurologico \"Carlo Besta\", Milano, Italy; Department of Neurology, Veterans Affairs Medical Center, Baltimore, MD, USA; Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA, Department of Public Health and Primary Care, University of Cambridge, UK, Center for Inherited Disease Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Longitudinal Studies Section, Clinical Research Branch, National Institute of Aging, National Institute of Health, Bethesda, MD, USA; Vascular Biology Unit, School of Medicine, James Cook University, Australia; Department of Neurology, Royal Perth Hospital, Australia; School of Medicine and Pharmacology, University of Western Australia, Australia; Department of Biostatistical Sciences, Wake Forest School of Medicine, NC, USA; Center for Cancer Genomics, Wake Forest School of Medicine, NC, USA; Stroke Research Programme, Schools of Medicine & Molecular Biomedical Science, University of Adelaide, Australia; Section of Neurology, Aga Khan University, Pakistan; Imperial College Cerebrovascular Research Unit (ICCRU), Imperial College London, UK; Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK; Centre for Bioinformatics, Biomarker Discovery and Information-based Medicine, The University of Newcastle, Australia; Neurosciences Department, Gosford Hospital, University of Newcastle, Australia; The Genomics and Randomized Trials Network; Department of Biochemistry and Molecular Genetics, University of Virginia, VA, USA; University of Pennsylvania, USA 40 Department of Neurology, University of Virginia, VA, USA (literal)

Titolo

Are myocardial infarction-associated single nucleotide polymorphisms associated with ischemic stroke? (literal)

Abstract

Background and Purpose Ischemic stroke (IS) shares many common risk factors with coronary artery disease (CAD). We hypothesized that genetic variants associated with myocardial infarction (MI) or CAD may be similarly involved in the etiology of IS. To test this hypothesis, we evaluated whether single nucleotide polymorphisms (SNPs) at 11 different loci recently associated with MI or CAD through genome-wide association studies were associated with IS. Methods Meta-analyses of the associations between the 11 MI-associated SNPs and IS were performed using 7,080 cases and 11,395 controls recruited from 9 studies. SNPs were either genotyped directly or imputed; in a few cases a surrogate SNP in high linkage disequilibrium was chosen. Logistic regression was performed within each study to obtain study-specific betas and standard errors. Meta-analysis was conducted using an inverse variance weighted approach assuming a random effect model. Results Despite having power to detect odds ratio of 1.09-1.14 for overall IS and 1.20-1.32 for major stroke subtypes, none of the SNPs were significantly associated with overall IS and/or stroke subtypes after adjusting for multiple comparisons. Conclusions Our results suggest that the major common loci associated with MI risk do not have effects of similar magnitude on overall IS, but do not preclude moderate associations restricted to specific IS subtypes. Disparate mechanisms may be critical in the development of acute ischemic coronary and cerebrovascular events. (literal)

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