Intracellular Shigella remodels its LPS to dampen the innate immune recognition and evade inflammasome activation (Articolo in rivista)

Type
Label
  • Intracellular Shigella remodels its LPS to dampen the innate immune recognition and evade inflammasome activation (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1073/pnas.1303641110 (literal)
Alternative label
  • Paciello, I; Silipo, A; Lembo-Fazio, L; Curcuru, L; Zumsteg, A; Noel, G; Ciancarella, V; Sturiale, L; Molinaro, A; Bernardini, ML. (2013)
    Intracellular Shigella remodels its LPS to dampen the innate immune recognition and evade inflammasome activation
    in Proceedings of the National Academy of Sciences of the United States of America
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Paciello, I; Silipo, A; Lembo-Fazio, L; Curcuru, L; Zumsteg, A; Noel, G; Ciancarella, V; Sturiale, L; Molinaro, A; Bernardini, ML. (literal)
Pagina inizio
  • E4345 (literal)
Pagina fine
  • E4354 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 110 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 10 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 46 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Univ Roma La Sapienza, Dipartimento Biol & Biotecnol Darwin C, I-00185 Rome, Italy. Univ Naples Federico II, Complesso Univ Monte Santangelo, Dipartimento Sci Chim, I-80126 Naples, Italy. Max Planck Inst Infect Biol, Dept Cellular Microbiol, D-10117 Berlin, Germany. CNR, Ist Chim & Tecnol Polimeri, I-95126 Catania, Italy. Univ Roma La Sapienza, Ist Pasteur Fdn Cenci Bolognetti, I-00185 Rome, Italy. (literal)
Titolo
  • Intracellular Shigella remodels its LPS to dampen the innate immune recognition and evade inflammasome activation (literal)
Abstract
  • LPS is a potent bacterial effector triggering the activation of the innate immune system following binding with the complex CD14, myeloid differentiation protein 2, and Toll-like receptor 4. The LPS of the enteropathogen Shigella flexneri is a hexa-acylated isoform possessing an optimal inflammatory activity. Symptoms of shigellosis are produced by severe inflammation caused by the invasion process of Shigella in colonic and rectal mucosa. Here we addressed the question of the role played by the Shigella LPS in eliciting a dysregulated inflammatory response of the host. We unveil that (i) Shigella is able to modify the LPS composition, e.g., the lipid A and core domains, during proliferation within epithelial cells; (ii) the LPS of intracellular bacteria (iLPS) and that of bacteria grown in laboratory medium differ in the number of acyl chains in lipid A, with iLPS being the hypoacylated; (iii) the immunopotential of iLPS is dramatically lower than that of bacteria grown in laboratory medium; (iv) both LPS forms mainly signal through the Toll-like receptor 4/myeloid differentiation primary response gene 88 pathway; (v) iLPS down-regulates the inflammasome-mediated release of IL-1 beta in Shigella-infected macrophages; and (vi) iLPS exhibits a reduced capacity to prime polymorfonuclear cells for an oxidative burst. We propose a working model whereby the two forms of LPS might govern different steps of the invasive process of Shigella. In the first phases, the bacteria, decorated with hypoacylated LPS, are able to lower the immune system surveillance, whereas, in the late phases, shigellae harboring immunopotent LPS are fully recognized by the immune system, which can then successfully resolve the infection. (literal)
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