Genetic loci for retinal arteriolar microcirculation (Articolo in rivista)

Type
Label
  • Genetic loci for retinal arteriolar microcirculation (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Alternative label
  • Xueling Sim1., Richard A. Jensen2,3., M. Kamran Ikram4,5., Mary Frances Cotch6., Xiaohui Li7,Stuart MacGregor8, Jing Xie9, Albert Vernon Smith10,11, Eric Boerwinkle12, Paul Mitchell13,Ronald Klein14, Barbara E. K. Klein14, Nicole L. Glazer2,15,16, Thomas Lumley2,17,18, BarbaraMcKnight2,17,Bruce M. Psaty2,3,15,19,20, Paulus T. V. M. de Jong21,22,23, Albert Hofman23, Fernando Rivadeneira23,24,Andre G.Uitterlinden23,24,25, Cornelia M. van Duijn23, Thor Aspelund10,11, Gudny Eiriksdottir10,Tamara B. Harris26, Fridbert Jonasson27,28, Lenore J. Launer26, The Wellcome Trust Case ControlConsortium2"a, John Attia 29,30, Paul N. Baird9, Stephen Harrap31, Elizabeth G. Holliday29,Michael Inouye32,33, Elena Rochtchina13, Rodney J. Scott34, Ananth Viswanathan35,36, Global BPGenConsortium"b, Guo Li2, Nicholas L. Smith3,20,37, Kerri L. Wiggins2,15, Jane Z. Kuo7, Kent D. Taylor7,Alex W. Hewitt9, Nicholas G. Martin8, Grant W. Montgomery8, Cong Sun38, Terri L. Young39,David A. Mackey9,40, Natalie R. van Zuydam41, Alex S. F. Doney41, Colin N. A. Palmer41,Andrew D. Morris41, Jerome I. Rotter 7, E. Shyong Tai42,43,44", Vilmundur Gudnason10,11",Johannes R. Vingerling5,23", David S. Siscovick2,3,15", Jie Jin Wang9,13", Tien Y. Wong4,9,45*. Collaborators (217) (2013)
    Genetic loci for retinal arteriolar microcirculation
    in PloS one
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Xueling Sim1., Richard A. Jensen2,3., M. Kamran Ikram4,5., Mary Frances Cotch6., Xiaohui Li7,Stuart MacGregor8, Jing Xie9, Albert Vernon Smith10,11, Eric Boerwinkle12, Paul Mitchell13,Ronald Klein14, Barbara E. K. Klein14, Nicole L. Glazer2,15,16, Thomas Lumley2,17,18, BarbaraMcKnight2,17,Bruce M. Psaty2,3,15,19,20, Paulus T. V. M. de Jong21,22,23, Albert Hofman23, Fernando Rivadeneira23,24,Andre G.Uitterlinden23,24,25, Cornelia M. van Duijn23, Thor Aspelund10,11, Gudny Eiriksdottir10,Tamara B. Harris26, Fridbert Jonasson27,28, Lenore J. Launer26, The Wellcome Trust Case ControlConsortium2\"a, John Attia 29,30, Paul N. Baird9, Stephen Harrap31, Elizabeth G. Holliday29,Michael Inouye32,33, Elena Rochtchina13, Rodney J. Scott34, Ananth Viswanathan35,36, Global BPGenConsortium\"b, Guo Li2, Nicholas L. Smith3,20,37, Kerri L. Wiggins2,15, Jane Z. Kuo7, Kent D. Taylor7,Alex W. Hewitt9, Nicholas G. Martin8, Grant W. Montgomery8, Cong Sun38, Terri L. Young39,David A. Mackey9,40, Natalie R. van Zuydam41, Alex S. F. Doney41, Colin N. A. Palmer41,Andrew D. Morris41, Jerome I. Rotter 7, E. Shyong Tai42,43,44\", Vilmundur Gudnason10,11\",Johannes R. Vingerling5,23\", David S. Siscovick2,3,15\", Jie Jin Wang9,13\", Tien Y. Wong4,9,45*. Collaborators (217) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • Gli autori dell'IRGB-CNR sono inclusi tra i collaboratori all'interno del Global BPGen Consortium (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America,2 Cardiovascular Health Research Unit, University of Washington,Seattle, Washington, United States of America,3Department of Epidemiology, University of Washington, Seattle, Washington, United States of America,4Singapore EyeResearch Institute, Singapore National Eye Centre, Singapore, Singapore,5Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands,6Division of Epidemiology and Clinical Applications, National EyeInstitute, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United Statesof America,7Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America,8Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Queensland, Australia,9Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital,Melbourne, Victoria, Australia,10Icelandic Heart Association, Kopavogur Capital Region, Iceland,11Department of Medicine, University of Iceland, Reykjavik, Iceland,12Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America,13Centrefor Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia, 14Department ofOphthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America,15Department of Medicine, University of Washington, Seattle, Washington, United States of America,16 Department of Medicine, Boston University, Boston, Massachusetts, United Statesof America,17 Department of Biostatistics, University of Washington, Seattle, Washington, United States of America,18Department of Statistics, University of Auckland,Auckland, New Zealand,19 Department of Health Services, University of Washington, Seattle, Washington, United States of America,20Group Health Research Institute,Group Health Cooperative, Seattle, Washington, United States of America,21Department of Clinical and Molecular Ophthalmogenetics, The Netherlands Institute ofNeuroscience, Amsterdam, The Netherlands,22Department of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands,23Department of Epidemiology,Erasmus Medical Center, Rotterdam, The Netherlands,24Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands,25Department ofClinical Chemistry, Erasmus Medical Center, Rotterdam, The Netherlands,26Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging,Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States of America, 27Department of Ophthalmology, University of Iceland,Reykjavik, Iceland,28Department of Ophthalmology, Landspitalinn University Hospital, Reykjavik, Iceland, 29School of Medicine and Public Health, University ofNewcastle, Newcastle, New South Wales, Australia,30Department of Medicine, John Hunter Hospital and Hunter Medical Research Institute, Newcastle, New South Wales,Australia,31Department of Physiology, University of Melbourne, Melbourne, Victoria, Australia,32Immunology Division, Walter and Eliza Hall Institute of MedicalResearch, Victoria, Australia,33Department of Medical Biology, University of Melbourne, Victoria, Australia,34School of Biomedical Sciences, University of Newcastle,Newcastle, New South Wales, Australia,35National Institutes of Health Research (NIHR) Biomedical Research Centre for Ophthalmology,Moorfields Eye Hospital, London,United Kingdom,36University College London Institute of Ophthalmology, London, United Kingdom,37Seattle Epidemiologic Research and Information Center,Veterans Affairs Office of Research and Development, Seattle, Washington, United States of America,38Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia,39Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States of America,40Lions Eye Institute,University of Western Australia, Centre for Ophthalmology and Visual Science, Perth, Western Australia, Australia,41Medical Research Institute, University of Dundee,Dundee, Scotland, United Kingdom,42 Department of Medicine, National University of Singapore, Singapore, Singapore,43Saw Swee Hock School of Public Health,National University of Singapore, Singapore, Singapore,44Duke-National University of Singapore Graduate Medical School, Singapore, Singapore,45Department ofOphthalmology, National University of Singapore, Singapore, Singapore (literal)
Titolo
  • Genetic loci for retinal arteriolar microcirculation (literal)
Abstract
  • Narrow arterioles in the retina have been shown to predict hypertension as well as other vascular diseases, likely through an increase in the peripheral resistance of the microcirculatory flow. In this study, we performed a genome-wide association study in 18,722 unrelated individuals of European ancestry from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium and the Blue Mountain Eye Study, to identify genetic determinants associated with variations in retinal arteriolar caliber. Retinal vascular calibers were measured on digitized retinal photographs using a standardized protocol. One variant (rs2194025 on chromosome 5q14 near the myocyte enhancer factor 2C MEF2C gene) was associated with retinal arteriolar caliber in the meta-analysis of the discovery cohorts at genome-wide significance of P-value <5×10(-8). This variant was replicated in an additional 3,939 individuals of European ancestry from the Australian Twins Study and Multi-Ethnic Study of Atherosclerosis (rs2194025, P-value = 2.11×10(-12) in combined meta-analysis of discovery and replication cohorts). In independent studies of modest sample sizes, no significant association was found between this variant and clinical outcomes including coronary artery disease, stroke, myocardial infarction or hypertension. In conclusion, we found one novel loci which underlie genetic variation in microvasculature which may be relevant to vascular disease. The relevance of these findings to clinical outcomes remains to be determined. (literal)
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