PKC alpha-mediated CREB activation is oxygen and age-dependent in rat myocardial tissue. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• PKC alpha-mediated CREB activation is oxygen and age-dependent in rat myocardial tissue. (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Alternative label

• Di Giulio C, Rapino M, Zingariello M, Antonucci A, Cataldi A. (2007)
  PKC alpha-mediated CREB activation is oxygen and age-dependent in rat myocardial tissue.
  in Histochemistry and cell biology
  (literal)

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• Di Giulio C, Rapino M, Zingariello M, Antonucci A, Cataldi A. (literal)

Pagina inizio

• 327 (literal)

Pagina fine

• 333 (literal)

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• 127 (literal)

Rivista

• Histochemistry and cell biology (Rivista)

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• Published Online: 31 May 2007 (literal)

Note

• ISI Web of Science (WOS) (literal)

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• Dipartimento di Scienze Mediche di Base ed Applicate, Università G. d’Annunzio, Chieti-Pescara, Chieti, Italy; Istituto per i Trapianti d’Organo e l’Immunocitologia del CNR, Chieti, Italy; Dipartimento di Biomorfologia, Università G.d’Annunzio, Chieti-Pescara, Via dei Vestini, 6, 66100 Chieti, Italy; Cattedra di Anatomia Umana, Facoltà di Farmacia, Università G. d’Annunzio, Chieti-Pescara, Chieti, Italy. (literal)

Titolo

• PKC alpha-mediated CREB activation is oxygen and age-dependent in rat myocardial tissue. (literal)

Abstract

• Both hypoxia and aging affect the morphology and the function of rat myocardial tissue. Moreover the heart tries to counteract the impaired function by activating specific signalling cascades. Here we report the involvement of CREB protein in \"in vivo\" response to hypoxic challenge and during aging in rat hearts. CREB is activated in parallel to HIF-1alpha nuclear translocation in the young after hypoxia exposure followed by reoxygenation, while this kind of response is not so dramatic in the old, neither in terms of CREB activation, neither in terms of HIF-1alpha expression and translocation, suggesting in the old the existence of an impaired oxygen-sensing mechanism or an adaptation of the cells to hypoxia. Moreover in the young a PKC alpha/Erk pathway seems to be involved in the activation of HIF-1alpha along with CREB, suggesting an attempt of the young to counteract the damage evoked by hypoxia, while in the old a PKC alpha/p38 MAPK/CREB pathway could determine the occurrence of both aging and aged cell hypoxia response (literal)

Prodotto di

• Patogenesi delle malattie degenerative muscolo-scheletriche (ME.P05.014.001) (Modulo)
• Institute of molecular genetics (IGM) (Istituto)

Autore CNR

• MONICA RAPINO (Persona)

Insieme di parole chiave

• Parole chiave di "PKC alpha-mediated CREB activation is oxygen and age-dependent in rat myocardial tissue." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MONICA RAPINO (Persona)

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Patogenesi delle malattie degenerative muscolo-scheletriche (ME.P05.014.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Histochemistry and cell biology (Rivista)

Insieme di parole chiave di

• Parole chiave di "PKC alpha-mediated CREB activation is oxygen and age-dependent in rat myocardial tissue." (Insieme di parole chiave)