Localization of Mitochondrial Carnitine/Acylcarnitine Translocase in Sensory Neurons from Rat Dorsal Root Ganglia (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Localization of Mitochondrial Carnitine/Acylcarnitine Translocase in Sensory Neurons from Rat Dorsal Root Ganglia (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s11064-013-1168-z (literal)

Alternative label

• Annamaria Tonazzi o Cristina Mantovani o Matilde Colella o Giorgio Terenghi o Cesare Indiveri (2013)
  Localization of Mitochondrial Carnitine/Acylcarnitine Translocase in Sensory Neurons from Rat Dorsal Root Ganglia
  in Neurochemical research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Annamaria Tonazzi o Cristina Mantovani o Matilde Colella o Giorgio Terenghi o Cesare Indiveri (literal)

Pagina inizio

• 2535 (literal)

Pagina fine

• 2541 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 38 (literal)

Rivista

• Neurochemical research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• A. Tonazzi (&) CNR Institute of Biomembranes and Bioenergetics, via Amendola165/A, 70126 Bari, Italy e-mail: a.tonazzi@ibbe.cnr.it A. Tonazzi ? M. Colella Department of Biosciences, Biotechnology and Biopharmaceutics, University of Bari ''Aldo Moro'', via Orabona 4, 70125 Bari, Italy C. Mantovani ? G. Terenghi Blond McIndoe Research Laboratory, Regenerative Biomedicine, University of Manchester, Oxford Road, Manchester M13 9PT, UK C. Mantovani Department of Pharmacological and Biomolecular Sciences, University of Milan, via Balzaretti 9, 20133 Milan, Italy C. Indiveri Unit of Biochemistry and Molecular Biotechnology, Department of BEST (Biologia, Ecologia e Scienze della Terra), University of Calabria, via P. Bucci 4-6C, 87036 Arcavacata di Rende, Italy (literal)

Titolo

• Localization of Mitochondrial Carnitine/Acylcarnitine Translocase in Sensory Neurons from Rat Dorsal Root Ganglia (literal)

Abstract

• The carnitine/acylcarnitine transporter is a transport system whose function is essential for the mitochondrial b-oxidation of fatty acids. Here, the presence of carnitine/acylcarnitine carrier (CACT) in nervous tissue and its sub-cellular localization in dorsal root ganglia (DRG) neurons have been investigated. Western blot analysis using a polyclonal anti-CACT antibody produced in our laboratory revealed the presence of CACT in all the nervous tissue extracts analyzed. Confocal microscopy experiments performed on fixed and permeabilized DRG neurons co-stained with the anti-CACT antibody and the mitochondrial marker MitoTracker Red clearly showed a mitochondrial localization for the carnitine/acylcarnitine transporter. The transport activity of CACT from DRG extracts reconstituted into liposomes was about 50 % in respect to liver extracts. The experimental data here reported represent the first direct evidence of the expression of the carnitine/acylcarnitine transporter in sensory neurons, thus supporting the existence of the b-oxidation pathway in these cells (literal)

Prodotto di

• Trasportatori mitocondriali: struttura e meccanismi funzionali (SV.P14.007.001) (Modulo)
• Istituto di biomembrane e bioenergetica (IBBE) (Istituto)

Autore CNR

• CESARE INDIVERI (Persona)
• ANNAMARIA TONAZZI (Persona)

Incoming links:

Prodotto

• Istituto di biomembrane e bioenergetica (IBBE) (Istituto)
• Trasportatori mitocondriali: struttura e meccanismi funzionali (SV.P14.007.001) (Modulo)

Autore CNR di

• ANNAMARIA TONAZZI (Persona)
• CESARE INDIVERI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neurochemical research (Rivista)