Meta-Analysis of Genome-Wide Association Studies in Myopia in Nine Populations. (Abstract/Poster in atti di convegno)

Type
Label
  • Meta-Analysis of Genome-Wide Association Studies in Myopia in Nine Populations. (Abstract/Poster in atti di convegno) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Alternative label
  • C. Simpson1, R. Wojciechowski2, V. Verhoeven3,4, P. Hysi5, M. Schache6, X. Li7, M. Hosseini8,9, L. Portas10, F. Murgia10, K. Oexle11,12, A. Paterson8,9, V. Vitart13, C. Hammond5, P. N. Baird6, M. Pirastu10, J. Rotter7, C. C. W. Klaver3,4, T. Meitinger11,12, D. Stambolian14, J. E. Bailey-Wilson1 (2013)
    Meta-Analysis of Genome-Wide Association Studies in Myopia in Nine Populations.
    in 63rd Annual Meeting of The American Society of Human Genetics, Date, Location, October 22-26, 2013 in Boston, Massachusetts, Boston, Massachusetts, 22-26 ottobre 2013
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • C. Simpson1, R. Wojciechowski2, V. Verhoeven3,4, P. Hysi5, M. Schache6, X. Li7, M. Hosseini8,9, L. Portas10, F. Murgia10, K. Oexle11,12, A. Paterson8,9, V. Vitart13, C. Hammond5, P. N. Baird6, M. Pirastu10, J. Rotter7, C. C. W. Klaver3,4, T. Meitinger11,12, D. Stambolian14, J. E. Bailey-Wilson1 (literal)
Note
  • Poster (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1) Inherited Disease Research Branch, NHGRI, NIH, Baltimore, MD; 2) Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA; 3) Department of Ophthalmology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands; 4) Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands; 5) Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK; 6) Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Australia; 7) Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; 8) Institute of Medical Science, University of Toronto, Toronto, Canada; 9) Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, Canada; 10) Institute of Population Genetics, National Research Council, Sassari, Italy; 11) Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany; 12) Institute of Human Genetics, Technical University Munich, Munich, Germany; 13) Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK; 14) Department of Ophthalmology, University of Pennsylvania, Philadelphia, USA. (literal)
Titolo
  • Meta-Analysis of Genome-Wide Association Studies in Myopia in Nine Populations. (literal)
Abstract
  • Myopia is a common refractive error which affects at least a third of most populations. Both genetic and environmental factors influence myopic development. It has a significant impact on the lives of affected individuals and carries high economic costs associated with treatment, loss of productivity and co-morbidity from vision impairment. Recent genome-wide association studies (GWAS) have identified a number of loci associated with myopia and refractive error. Here we report results of a large meta-analysis of myopia in nine cohorts, for a total of 17,787 individuals of European ancestry and replication in a further 8 cohorts for a total of 7953 individuals. Genotypes in each population were imputed to HapMap2 and analyzed separately by each group. Cases were defined as a spherical equivalent of -1 diopters (D) or worse and controls were defined as > 0D. Individuals between 0 and -1D were coded as unknown. Analyses were performed including age, sex and years of education, plus the first 3 principal components to adjust for population structure. Meta-analysis was performed in METAL using the sample size schema. Due to large differences in numbers of cases and controls for some studies, effective sample sizes were calculated using the formula recommended by the authors of METAL. Genomic control was used to adjust for any residual structural differences between populations. 3 SNPS were identified as genome-wide significant with P < 5e-8, rs10113215 on chromosome 8q12.1 and rs1370156 and rs2028099 both in a previously reported locus on chromosome 15q14. For replication, SNPs with P < 1e-5 were identified and all SNPs within 500kb each side of that SNP selected, for a total of 20,431 SNPs. The replication threshold was set by calculating the effective degrees of freedom using the Ramos method. SNPs will be considered to replicate where the p value < 0.0026. The replication analyses are ongoing and will be presented. (literal)
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
data.CNR.it