Adult c-kit(pos) cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Adult c-kit(pos) cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair. (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.cell.2013.07.039 (literal)

Alternative label

• Ellison GM, Vicinanza C, Smith AJ, Aquila I, Leone A, Waring CD, Henning BJ, Stirparo GG, Papait R, Scarfò M, Agosti V, Viglietto G, Condorelli G, Indolfi C, Ottolenghi S, Torella D, Nadal-Ginard B. (2013)
  Adult c-kit(pos) cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair.
  in Cell (Cambridge)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ellison GM, Vicinanza C, Smith AJ, Aquila I, Leone A, Waring CD, Henning BJ, Stirparo GG, Papait R, Scarfò M, Agosti V, Viglietto G, Condorelli G, Indolfi C, Ottolenghi S, Torella D, Nadal-Ginard B. (literal)

Pagina inizio

• 827 (literal)

Pagina fine

• 842 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 154 (literal)

Rivista

• Cell (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 15 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Stem Cell and Regenerative Biology Unit (BioStem), Liverpool John Moores University, Liverpool L3 3AF, UK Laboratory of Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro 88100, Italy Laboratory of Molecular Oncology, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro 88100, Italy CIS for Genomics and Molecular Pathology, Magna Graecia University, Catanzaro 88100, Italy Centre of Human and Aerospace Physiological Sciences, School of Biomedical Sciences, King's College, London, Guy's Campus, London SE1 1UL, UK Centre for Stem Cells and Regenerative Medicine, King's College, London, Guy's Campus, London SE1 1UL, UK Humanitas Clinical and Research Center, Rozzano-Milan 20098, Italy Institute of Genetics and Biomedical Research, National Research Council of Italy (CNR), Rozzano-Milan 20098, Italy IRGS-Biogem, Ariano Irpino, Avellino 83031, Italy University of Milan, Milan 20098, Italy Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milan 20126, Italy (literal)

Titolo

• Adult c-kit(pos) cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair. (literal)

Abstract

• The epidemic of heart failure has stimulated interest in understanding cardiac regeneration. Evidence has been reported supporting regeneration via transplantation of multiple cell types, as well as replication of postmitotic cardiomyocytes. In addition, the adult myocardium harbors endogenous c-kitpos cardiac stem cells (eCSCs), whose relevance for regeneration is controversial. Here, using different rodent models of diffuse myocardial damage causing acute heart failure, we show that eCSCs restore cardiac function by regenerating lost cardiomyocytes. Ablation of the eCSC abolishes regeneration and functional recovery. The regenerative process is completely restored by replacing the ablated eCSCs with the progeny of one eCSC. eCSCs recovered from the host and recloned retain their regenerative potential in vivo and in vitro. After regeneration, selective suicide of these exogenous CSCs and their progeny abolishes regeneration, severely impairing ventricular performance. These data show that c-kitpos eCSCs are necessary and sufficient for the regeneration and repair of myocardial damage. (literal)

Prodotto di

• EPIGENETICA DELLE MALATTIE CARDIOVASCOLARI (ME.P05.021.004) (Modulo)
• Istituto di Ricerca Genetica e Biomedica (IRGB) (Istituto)

Autore CNR

• ROBERTO PAPAIT (Unità di personale interno)

Incoming links:

Prodotto

• Istituto di Ricerca Genetica e Biomedica (IRGB) (Istituto)
• EPIGENETICA DELLE MALATTIE CARDIOVASCOLARI (ME.P05.021.004) (Modulo)

Autore CNR di

• ROBERTO PAPAIT (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cell (Rivista)