http://www.cnr.it/ontology/cnr/individuo/prodotto/ID273582
Uric acid is the major determinant of absorbance in spent dialysate allowing spectrophotometric evaluation of dialysis dose (Articolo in rivista)
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- Uric acid is the major determinant of absorbance in spent dialysate allowing spectrophotometric evaluation of dialysis dose (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1007/s40620-013-0003-6 (literal)
- Alternative label
Carlo Donadio o Dario Calia o Silvia Ghimenti o
Massimo Onor o Elisa Colombini o Roger Fuoco o
Fabio Di Francesco (2013)
Uric acid is the major determinant of absorbance in spent dialysate allowing spectrophotometric evaluation of dialysis dose
in JN. Journal of Nephrology (Milano, 1992); Springer, Milano-Heidelberg-New York (Italia)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Carlo Donadio o Dario Calia o Silvia Ghimenti o
Massimo Onor o Elisa Colombini o Roger Fuoco o
Fabio Di Francesco (literal)
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- University of Pisa, Pisa, Italy (literal)
- Titolo
- Uric acid is the major determinant of absorbance in spent dialysate allowing spectrophotometric evaluation of dialysis dose (literal)
- Abstract
- Background Ultraviolet (UV) absorbance of spent dialysate
has been proposed as a method for monitoring hemodialysis
efficiency. The contribution of the various
uremic toxins to UV absorption, however, needs clarifying.
Methods Urea, creatinine and uric acid were measured in
blood and dialysate before and during dialysis in 22
maintenance hemodialysis patients. Absorbance was measured
in dialysate.
Results High-performance liquid chromatography (HPLC)
analyses of dialysate revealed uric acid as the predominant
peak. Spent dialysate absorbance decreased, during dialysis,
similarly to serumand dialysate urea, creatinine and uric acid.
Dialysate urea correlated closely with absorbance, though
urea did not contribute to absorbance, which was determined
mostly by uric acid. Uric acid and urea removals were very
similar. The spectrophotometric Kt/V correlated with spKt/V
urea, with slight but significant differences between the two
measurements.
Conclusions UV absorbance is determined mostly by uric
acid. Absorbance measurements seem suitable as a method
for monitoring dialysis efficiency. (literal)
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