THE EMERGING PHYSIOLOGICAL ROLES OF THE GLYCEROPHOSPHODIESTERASE FAMILY (Rassegna e recensione)

Type
Label
  • THE EMERGING PHYSIOLOGICAL ROLES OF THE GLYCEROPHOSPHODIESTERASE FAMILY (Rassegna e recensione) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Alternative label
  • Daniela Corda1, Maria G. Mosca1, Noriyasu Ohshima2, Laura Grauso3, Noriyuki Yanaka4 and Stefania Mariggiò1,* (2014)
    THE EMERGING PHYSIOLOGICAL ROLES OF THE GLYCEROPHOSPHODIESTERASE FAMILY
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Daniela Corda1, Maria G. Mosca1, Noriyasu Ohshima2, Laura Grauso3, Noriyuki Yanaka4 and Stefania Mariggiò1,* (literal)
Pagina inizio
  • 998 (literal)
Pagina fine
  • 1016 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 281 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 18 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 4 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Institute of Protein Biochemistry, National Research Council, Naples, Italy 2 Department of Biochemistry, Gunma University Graduate School of Medicine, Japan 3 Institute of Biomolecular Chemistry, National Research Council, Naples, Italy 4 Department of Molecular and Applied Bioscience, Graduate School of Biosphere Science, Hiroshima University, Japan (literal)
Titolo
  • THE EMERGING PHYSIOLOGICAL ROLES OF THE GLYCEROPHOSPHODIESTERASE FAMILY (literal)
Abstract
  • The glycerophosphodiester phosphodiesterases are evolutionarily conserved proteins that have been linked to several patho/physiological functions, comprising bacterial pathogenicity and mammalian cell proliferation or differentiation. The bacterial enzymes do not show preferential substrate selectivities among the glycerophosphodiesters, and they are mainly dedicated to glycerophosphodiester hydrolysis, producing glycerophosphate and alcohols as the building blocks that are required for bacterial biosynthetic pathways. In some cases, this enzymatic activity has been demonstrated to contribute to bacterial pathogenicity, such as with Hemophilus influenzae. Mammalian glyerophosphodiesterases have high substrate specificities, even if the number of potential physiological substrates is continuously increasing. Some of these mammalian enzymes have been directly linked to cell differentiation, such as GDE2, which triggers motor neuron differentiation, and GDE3, the enzymatic activity of which is necessary and sufficient to induce osteoblast differentiation. Instead, GDE5 has been shown to inhibit skeletal muscle development independent of its enzymatic activity. (literal)
Editore
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Editore di
Insieme di parole chiave di
data.CNR.it