Nevirapine-selected mutations Y181I/C of HIV-1 reverse transcriptase confer cross-resistance to stavudine (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Nevirapine-selected mutations Y181I/C of HIV-1 reverse transcriptase confer cross-resistance to stavudine (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Baldanti F, Paolucci S, Maga G, Labo N, Hubscher U, Skoblov AY, Victorova L, Spadari S, Minoli L, Gerna G. (2003)
  Nevirapine-selected mutations Y181I/C of HIV-1 reverse transcriptase confer cross-resistance to stavudine
  in AIDS (Lond.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Baldanti F, Paolucci S, Maga G, Labo N, Hubscher U, Skoblov AY, Victorova L, Spadari S, Minoli L, Gerna G. (literal)

Pagina inizio

• 1568 (literal)

Pagina fine

• 1570 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 17 (literal)

Rivista

• AIDS (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• Impact Factor: 5.521 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Genetica Molecolare, Servizio di Virologia, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico S. Matteo, Pavia, Italy, the Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia, Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich-Irchel, Switzerland (literal)

Titolo

• Nevirapine-selected mutations Y181I/C of HIV-1 reverse transcriptase confer cross-resistance to stavudine (literal)

Abstract

• Stavudine administration did not increase the frequency of Y181I/C reverse transcriptase (RT) mutations in non-nucleoside reverse transcriptase inhibitor (NNRTI)-treated patients. However, recombinant Y181C HIV-1 showed reduced stavudine susceptibility with respect to both recombinant wild-type and K103N HIV-1 strains. In addition, recombinant Y181I RT enzyme showed reduced susceptibility to stavudine with respect to both wild-type and K103N RT. A previously unnoticed role of Y181I/C RT changes selected by nevirapine or other NNRTI in determining stavudine resistance is documented. (literal)

Prodotto di

• Institute of molecular genetics (IGM) (Istituto)

Autore CNR

• SILVIO SPADARI (Unità di personale interno)
• GIOVANNI MAGA (Persona)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)

Autore CNR di

• GIOVANNI MAGA (Persona)
• SILVIO SPADARI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• AIDS (Rivista)