Pyrazole-type cannabinoid ligands conjugated with fluoro-deoxy-carbohydrates as potential PET-imaging agents: Synthesis and CB1/CB2 receptor affinity evaluation (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Pyrazole-type cannabinoid ligands conjugated with fluoro-deoxy-carbohydrates as potential PET-imaging agents: Synthesis and CB1/CB2 receptor affinity evaluation (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.jfluchem.2013.03.006 (literal)

Alternative label

• Frau, Simona; Dall'Angelo, Sergio; Baillie, Gemma L.; Ross, Ruth A.; Pira, Marilena; Tseng, Chih-Chung; Lazzari, Paolo; Zanda, Matteo (2013)
  Pyrazole-type cannabinoid ligands conjugated with fluoro-deoxy-carbohydrates as potential PET-imaging agents: Synthesis and CB1/CB2 receptor affinity evaluation
  in Journal of fluorine chemistry (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Frau, Simona; Dall'Angelo, Sergio; Baillie, Gemma L.; Ross, Ruth A.; Pira, Marilena; Tseng, Chih-Chung; Lazzari, Paolo; Zanda, Matteo (literal)

Pagina inizio

• 166 (literal)

Pagina fine

• 172 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 152 (literal)

Rivista

• Journal of fluorine chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Note

• ISI Web of Science (WoS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• University of Aberdeen; Neurosci PharmaNess Scarl; University of Sassari; CNR ICRM (literal)

Titolo

• Pyrazole-type cannabinoid ligands conjugated with fluoro-deoxy-carbohydrates as potential PET-imaging agents: Synthesis and CB1/CB2 receptor affinity evaluation (literal)

Abstract

• A novel class of cannabinoid ligands was synthesized in good overall yields by means of oxime-bio-conjugation between hydroxylamine-functionalized Rimonabant-type pyrazoles and fluoro-deoxy-carbohydrates (D-2-fluoro-deoxy-glucose, FDG, and D-5-fluoro-5-deoxy-ribose, FDR). FDR proved to be superior to FDG for bio-conjugation, as it occurred in milder conditions and at faster rate (rt, 20 min vs. 100 degrees C, 30 min). All of the title compounds showed relatively modest affinity for the CBI receptor (high nanomolar range) and selectivities vs. the CB2. (C) 2013 Elsevier B.V. All rights reserved. (literal)

Prodotto di

• Istituto di chimica del riconoscimento molecolare (ICRM) (Istituto)
• Targeting e inibizione dell'angiogenesi per la terapia anti-cancro (PM.P01.021.004) (Modulo)

Autore CNR

• MATTEO ZANDA (Persona)

Insieme di parole chiave

• Keywords of "Pyrazole-type cannabinoid ligands conjugated with fluoro-deoxy-carbohydrates as potential PET-imaging agents: Synthesis and CB1/CB2 receptor affinity evaluation" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MATTEO ZANDA (Persona)

Prodotto

• Istituto di chimica del riconoscimento molecolare (ICRM) (Istituto)
• Targeting e inibizione dell'angiogenesi per la terapia anti-cancro (PM.P01.021.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of fluorine chemistry (Rivista)

Insieme di parole chiave di

• Keywords of "Pyrazole-type cannabinoid ligands conjugated with fluoro-deoxy-carbohydrates as potential PET-imaging agents: Synthesis and CB1/CB2 receptor affinity evaluation" (Insieme di parole chiave)