Impact of phosphorylation on the encapsulation of nucleoside analogues within porous iron(III) metal-organic framework MIL-100(Fe) nanoparticles (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Impact of phosphorylation on the encapsulation of nucleoside analogues within porous iron(III) metal-organic framework MIL-100(Fe) nanoparticles (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1039/c3tb20653j (literal)

Alternative label

• Agostoni, Valentina and Anand, Resmi and Monti, Sandra and Hall, Shaun and Maurin, Guillaume and Horcajada, Patricia and Serre, Christian and Bouchemal, Kawthar and Gref, Ruxandra (2013)
  Impact of phosphorylation on the encapsulation of nucleoside analogues within porous iron(III) metal-organic framework MIL-100(Fe) nanoparticles
  in Journal of Materials Chemistry B
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Agostoni, Valentina and Anand, Resmi and Monti, Sandra and Hall, Shaun and Maurin, Guillaume and Horcajada, Patricia and Serre, Christian and Bouchemal, Kawthar and Gref, Ruxandra (literal)

Pagina inizio

• 4231 (literal)

Pagina fine

• 4242 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 1 (literal)

Rivista

• Journal of Materials Chemistry B (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 34 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Agostoni V. and Bouchemal K and Gref R., Faculte' de Pharmacie, UMR 8612 CNRS, Universit´e Paris-Sud, Ch^atenay-Malabry, France. Anand R. and Monti S., CNR-Istituto per la Sintesi Organica e la Fotoreattivit`a, Bologna, Italy Hall S. and Maurin G. , Institut Charles Gerhardt Montpellier, UMR 5253 CNRS, UM2, UM1, ENSCM, Montpellier, France Horcajada P. and Serre C., Institut Lavoisier, UMR 8180 CNRS Universit´e de Versailles St Quentin en Yvelines, Versailles, France (literal)

Titolo

• Impact of phosphorylation on the encapsulation of nucleoside analogues within porous iron(III) metal-organic framework MIL-100(Fe) nanoparticles (literal)

Abstract

• Encapsulation of azidothymidine (AZT) or its phosphorylated derivatives (AZT-MP and AZT-TP) has been performed using nanoparticles of the porous crystalline iron(III) trimesate metal-organic framework MIL-100(Fe). The number of phosphate groups per nucleoside analogue has a high impact on the drug loading capacity, and their interaction with the Lewis acid sites from the nanoMOFs is also discussed through a combination of techniques such as UV-vis absorption, circular dichroism, isothermal titration calorimetry, HPLC and molecular simulations. Finally, the effect of the differences in terms of host-guest interactions is discussed through the release in physiological buffers of AZT, AZT-MP and AZT-TP. New perspectives for the nanoencapsulation of monophosphorylated nucleoside analogues for effective anti-cancer and anti-viral therapies are then discussed. (literal)

Prodotto di

• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)
• Studio delle interazioni legando-recettore in sistemi modello mediante metodi spettroscopici e fotofisici (LEGARE) (PM.P06.005.002) (Modulo)

Autore CNR

• SANDRA MONTI (Unità di personale esterno)
• RESMI ANAND (Persona)

Incoming links:

Prodotto

• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)
• Studio delle interazioni legando-recettore in sistemi modello mediante metodi spettroscopici e fotofisici (LEGARE) (PM.P06.005.002) (Modulo)

Autore CNR di

• RESMI ANAND (Persona)
• SANDRA MONTI (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of Materials Chemistry B (Rivista)