Towards an Improved anti-HIV Activity of NRTI via Metal-Organic Frameworks Nanoparticles (Articolo in rivista)

Type
Label
  • Towards an Improved anti-HIV Activity of NRTI via Metal-Organic Frameworks Nanoparticles (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/adhm.201200454 (literal)
Alternative label
  • Agostoni, Valentina and Chalati, Tamim and Horcajada, Patricia and Willaime, Hervé and Anand, Resmi and Semiramoth, Nicolas and Baati, Tarek and Hall, Shaun and Maurin, Guillaume and Chacun, Hélène and Bouchemal, Kawthar and Martineau, Charlotte and Taulelle, Francis and Couvreur, Patrick and Rogez-Kreuz, Christine and Clayette, Pascal and Monti, Sandra and Serre, Christian and Gref, Ruxandra (2013)
    Towards an Improved anti-HIV Activity of NRTI via Metal-Organic Frameworks Nanoparticles
    in Advanced healthcare materials (Internet)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Agostoni, Valentina and Chalati, Tamim and Horcajada, Patricia and Willaime, Hervé and Anand, Resmi and Semiramoth, Nicolas and Baati, Tarek and Hall, Shaun and Maurin, Guillaume and Chacun, Hélène and Bouchemal, Kawthar and Martineau, Charlotte and Taulelle, Francis and Couvreur, Patrick and Rogez-Kreuz, Christine and Clayette, Pascal and Monti, Sandra and Serre, Christian and Gref, Ruxandra (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://dx.doi.org/10.1002/adhm.201200454 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dr. V. Agostoni, Dr. T. Chalati, Dr. H. Willaime, Dr. N. Semiramoth, H. Chacun, Dr. K. Bouchemal, Prof. P. Couvreur, Dr. R. Gref Institut Galien, UMR 8612 CNRS Université Paris-Sud Châtenay-Malabry, France Dr. P. Horcajada, Dr. T. Baati, Dr. C. Martineau, Dr. F. Taulelle Dr. C. Serre Institut Lavoisier UMR 8180 CNRS Université de Versailles Versailles, France Dr. R. Anand, Dr. S. Monti CNR-Istituto per la Sintesi Organica e la Fotoreattività Bologna, Italy Dr. S. Hall, Dr G. Maurin Institut Charles Gerhardt Montpellier UMR 5253 CNRS, UM2, UM1, ENSCM Montpellier, France Dr. C. Rogez-Kreuz, Dr. P. Clayette Laboratoire de Neurovirologie Bertin Pharma, CEA Fontenay aux Roses, France (literal)
Titolo
  • Towards an Improved anti-HIV Activity of NRTI via Metal-Organic Frameworks Nanoparticles (literal)
Abstract
  • Nanoscale mesoporous iron carboxylates metal-organic frameworks (nano- MOFs) have recently emerged as promising platforms for drug delivery, showing biodegradability, biocompatibility and important loading capability of challenging highly water-soluble drugs such as azidothymidine tryphosphate (AZT-TP). In this study, nanoMOFs made of iron trimesate (MIL-100) were able to act as effi cient molecular sponges, quickly adsorbing up to 24 wt% AZT-TP with entrapment effi ciencies close to 100%, without perturbation of the supramolecular crystalline organization. These data are in agreement with molecular modelling predictions, indicating maximal loadings of 33 wt% and preferential location of the drug in the large cages. Spectrophotometry, isothermal titration calorimetry and solid state NMR investigations enabled to gain insight on the mechanism of interaction of AZT and AZT-TP with the nanoMOFs, pointing out the crucial role of phosphates strongly coordinating with the unsaturated iron(III) sites. Finally, contrarily to the free AZT-TP, the loaded nanoparticles effi ciently penetrate and release their cargo of active triphosphorylated AZT inside major HIV target cells, effi ciently protecting against HIV infection. (literal)
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