Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1074/jbc.M113.484337 (literal)

Alternative label

• Francesco Spallotta 1; Silvia Tardivo 2; Simona Nanni 3,7; Jessica D. Rosati 1; Stefania Straino 2 ,4 ; Antonello Mai 5; Matteo Vecellio1; Sergio Valente 5; Maurizio C. Capogrossi 3; Antonella Farsetti 7,6; Julie Martone 8; Irene Bozzoni 8; Alfredo Pontecorvi 3; Carlo Gaetano 9; Claudia Colussi 3,7 (2013)
  Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia
  in The Journal of biological chemistry (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Francesco Spallotta 1; Silvia Tardivo 2; Simona Nanni 3,7; Jessica D. Rosati 1; Stefania Straino 2 ,4 ; Antonello Mai 5; Matteo Vecellio1; Sergio Valente 5; Maurizio C. Capogrossi 3; Antonella Farsetti 7,6; Julie Martone 8; Irene Bozzoni 8; Alfredo Pontecorvi 3; Carlo Gaetano 9; Claudia Colussi 3,7 (literal)

Pagina inizio

• 22915 (literal)

Pagina fine

• 22929 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Epub 2013 Jul 7. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 288 (literal)

Rivista

• ?The ?Journal of biological chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 32 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 Laboratorio di Biologia Vascolare e Medicina Rigenerativa, Centro Cardiologico Monzino, 20138 Milano, Italy. 2 Laboratorio di Patologia Vascolare, Istituto Dermopatico dell'Immacolata, 00167 Roma, Italy. 3 Istituto di Patologia Medica, Università Cattolica del Sacro Cuore, 00168 Roma, Italy. 4 Explora Biotech, 00131 Roma, Italy. 5 Dipartimento di Scienze Chimiche, SAPIENZA University of Rome, 00185 Roma, Italy. 6 Istituto di Biologia Cellulare e Neurobiologia, Consiglio Nazionale delle Ricerche, 00143 Roma, Italy. 7 Department of Experimental Oncology, National Cancer Institute Regina Elena, 00158 Roma, Italy. 8 Institute Pasteur Cenci-Bolognetti, Department of Genetics and Molecular Biology and Istituto di Biologia e Patologia Molecolare, SAPIENZA University of Rome, 00185 Roma, Italy. 9 Division of Cardiovascular Epigenetics, Department of Cardiology, Goethe University, 60325 Frankfurt am Main, Germany. (literal)

Titolo

• Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia (literal)

Abstract

• Histone deacetylase inhibitors (DIs) are promising drugs for the treatment of several pathologies including ischemic and failing heart where they demonstrated efficacy. However, adverse side effects and cardiotoxicity have also been reported. Remarkably, no information is available about the effect of DIs during tissue regeneration following acute peripheral ischemia. In this study, mice made ischemic by femoral artery excision were injected with the DIs MS275 and MC1568, selective for class I and IIa histone deacetylases (HDACs), respectively. In untreated mice, soon after damage, class IIa HDAC phosphorylation and nuclear export occurred, paralleled by dystrophin and neuronal nitric-oxide synthase (nNOS) down-regulation and decreased protein phosphatase 2A activity. Between 14 and 21 days after ischemia, dystrophin and nNOS levels recovered, and class IIa HDACs relocalized to the nucleus. In this condition, the MC1568 compound increased the number of newly formed muscle fibers but delayed their terminal differentiation, whereas MS275 abolished the early onset of the regeneration process determining atrophy and fibrosis. The selective DIs had differential effects on the vascular compartment: MC1568 increased arteriogenesis whereas MS275 inhibited it. Capillarogenesis did not change. Chromatin immunoprecipitations revealed that class IIa HDAC complexes bind promoters of proliferation-associated genes and of class I HDAC1 and 2, highlighting a hierarchical control between class II and I HDACs during tissue regeneration. Our findings indicate that class-selective DIs interfere with normal mouse ischemic hindlimb regeneration and suggest that their use could be limited by alteration of the regeneration process in peripheral ischemic tissues. (literal)

Prodotto di

• ex ME.P03.007.001 / Meccanismi regolativi del Differenziamento e Oncogenesi (ME.P03.007.002) (Modulo)

Autore CNR

• ANTONELLA FARSETTI (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANTONELLA FARSETTI (Unità di personale interno)

Prodotto

• ex ME.P03.007.001 / Meccanismi regolativi del Differenziamento e Oncogenesi (ME.P03.007.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• ?The ?Journal of biological chemistry (Rivista)

Insieme di parole chiave di

• Keywords of "Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia" (Insieme di parole chiave)