Design of a novel LOX-1 receptor antagonist mimicking the natural substrate (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Design of a novel LOX-1 receptor antagonist mimicking the natural substrate (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.bbrc.2013.07.073 (literal)

Alternative label

• Falconi, Mattia; Ciccone, Sarah; D'Arrigo, Paola; Viani, Fiorenza; Sorge, Roberto; Novelli, Giuseppe; Patrizi, Patrizia; Desideri, Alessandro; Biocca, Silvia (2013)
  Design of a novel LOX-1 receptor antagonist mimicking the natural substrate
  in Biochemical and biophysical research communications (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Falconi, Mattia; Ciccone, Sarah; D'Arrigo, Paola; Viani, Fiorenza; Sorge, Roberto; Novelli, Giuseppe; Patrizi, Patrizia; Desideri, Alessandro; Biocca, Silvia (literal)

Pagina inizio

• 340 (literal)

Pagina fine

• 345 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 438 (literal)

Rivista

• Biochemical and biophysical research communications (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 6 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WoS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• University of Rome Tor Vergata; University of Rome Tor Vergata; University of Rome Tor Vergata; Polytechnic University of Milan; Polytechnic University of Milan; Consiglio Nazionale delle Ricerche (CNR); University of Rome Tor Vergata; BIOS FIANO Srl (literal)

Titolo

• Design of a novel LOX-1 receptor antagonist mimicking the natural substrate (literal)

Abstract

• The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), the major receptor for oxidized low-density lipoprotein (ox-LDL) in endothelial cells, is overexpressed in atherosclerotic lesions. LOX-1 specific inhibitors, urgently necessary to reduce the rate of atherosclerotic and inflammation processes, are not yet available. We have designed and synthesized a new modified oxidized phospholipid, named PLAzPC, which plays to small scale the ligand-receptor recognition scheme. Molecular docking simulations confirm that PLAzPC disables the hydrophobic component of the ox-LDL recognition domain and allows the interaction of the L-lysine backbone charged groups with the solvent and with the charged/polar residues located around the edges of the LOX-1 hydrophobic tunnel. Binding assays, in a cell model system expressing human LOX-1 receptors, confirm that PLAzPC markedly inhibits ox-LDL binding to LOX-1 with higher efficacy compared to previously identified inhibitors. (C) 2013 Elsevier Inc. All rights reserved. (literal)

Prodotto di

• Applicazioni sintetiche della biocatalisi (PM.P03.009.002) (Modulo)
• Istituto di chimica del riconoscimento molecolare (ICRM) (Istituto)

Autore CNR

• FIORENZA VIANI (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Design of a novel LOX-1 receptor antagonist mimicking the natural substrate" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• FIORENZA VIANI (Unità di personale interno)

Prodotto

• Istituto di chimica del riconoscimento molecolare (ICRM) (Istituto)
• Applicazioni sintetiche della biocatalisi (PM.P03.009.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biochemical and biophysical research communications (Rivista)

Insieme di parole chiave di

• Keywords of "Design of a novel LOX-1 receptor antagonist mimicking the natural substrate" (Insieme di parole chiave)