Enzymatic synthesis of new C-6-acylated derivatives of NAG-thiazoline and evaluation of their inhibitor activities towards fungal beta-N-acetylhexosaminidase (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Enzymatic synthesis of new C-6-acylated derivatives of NAG-thiazoline and evaluation of their inhibitor activities towards fungal beta-N-acetylhexosaminidase (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.molcatb.2012.10.016 (literal)

Alternative label

• Krejzova, Jana; Simon, Petr; Vavrikova, Eva; Slamova, Kristyna; Pelantova, Helena; Riva, Sergio; Spiwok, Vojtech; Kren, Vladimir (2013)
  Enzymatic synthesis of new C-6-acylated derivatives of NAG-thiazoline and evaluation of their inhibitor activities towards fungal beta-N-acetylhexosaminidase
  in Journal of molecular catalysis. B, Enzymatic (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Krejzova, Jana; Simon, Petr; Vavrikova, Eva; Slamova, Kristyna; Pelantova, Helena; Riva, Sergio; Spiwok, Vojtech; Kren, Vladimir (literal)

Pagina inizio

• 128 (literal)

Pagina fine

• 134 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 87 (literal)

Rivista

• Journal of molecular catalysis. B, Enzymatic (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Note

• ISI Web of Science (WoS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Czech Academy of Sciences; Consiglio Nazionale delle Ricerche (CNR); University of Chemistry and Technology, Prague (literal)

Titolo

• Enzymatic synthesis of new C-6-acylated derivatives of NAG-thiazoline and evaluation of their inhibitor activities towards fungal beta-N-acetylhexosaminidase (literal)

Abstract

• beta-N-Acetylhexosaminidases (EC 3.2.1.52) from the CAZy glycoside hydrolase families 20 and 84 are two distinct enzyme groups with similar reactivity and different physiological functions, thus selective inhibition of these enzymes is of crucial importance. Here, we report on the lipase-catalyzed synthesis of a set of novel monomeric and dimeric C-6-acylated derivatives of NAG-thiazoline, which is a typical competitive inhibitor of both these enzyme classes. The prepared compounds were tested as potential inhibitors of a fungal GH20 beta-N-acetylhexosaminidase from Talaromyces flavus, however, the results of the inhibition tests were quite ambiguous. The observed inhibition was generally weak with some features of competitive inhibition (increase of K-M), but the overall pattern appeared indecisive. (C) 2012 Elsevier B.V. All rights reserved. (literal)

Prodotto di

• Applicazioni sintetiche della biocatalisi (PM.P03.009.002) (Modulo)
• Istituto di chimica del riconoscimento molecolare (ICRM) (Istituto)

Autore CNR

• SERGIO RIVA (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Enzymatic synthesis of new C-6-acylated derivatives of NAG-thiazoline and evaluation of their inhibitor activities towards fungal beta-N-acetylhexosaminidase" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• SERGIO RIVA (Unità di personale interno)

Prodotto

• Istituto di chimica del riconoscimento molecolare (ICRM) (Istituto)
• Applicazioni sintetiche della biocatalisi (PM.P03.009.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of molecular catalysis. B, Enzymatic (Rivista)

Insieme di parole chiave di

• Keywords of "Enzymatic synthesis of new C-6-acylated derivatives of NAG-thiazoline and evaluation of their inhibitor activities towards fungal beta-N-acetylhexosaminidase" (Insieme di parole chiave)