Mouse Models for Down Syndrome-Associated Developmental Cognitive Disabilities (Articolo in rivista)

Type
Label
  • Mouse Models for Down Syndrome-Associated Developmental Cognitive Disabilities (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1159/000329422 (literal)
Alternative label
  • Liu C(2); Belichenko PV(5); Zhang L(2); Fu D(2); Kleschevnikov AM(5); Baldini A(6); Antonarakis SE(7); Mobley WC(5); Yu YE(1,2,3,4). (2011)
    Mouse Models for Down Syndrome-Associated Developmental Cognitive Disabilities
    in Developmental neuroscience
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Liu C(2); Belichenko PV(5); Zhang L(2); Fu D(2); Kleschevnikov AM(5); Baldini A(6); Antonarakis SE(7); Mobley WC(5); Yu YE(1,2,3,4). (literal)
Pagina inizio
  • 404 (literal)
Pagina fine
  • 413 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 33 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • PMID: 21865664 e-pub (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 10 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Pubblicazione (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. Roswell Pk Canc Inst, Ctr Genet & Pharmacol, Childrens Guild Fdn Down Syndrome Res Program, Buffalo, NY 14263 USA 2. Roswell Pk Canc Inst, Dept Canc Genet, Buffalo, NY 14263 USA 3. SUNY Buffalo, Grad Sch, Roswell Pk Div, New York State Ctr Excellence Bioinformat & Life, Buffalo, NY 14260 USA 4. SUNY Buffalo, Grad Sch, Roswell Pk Div, Dept Cellular & Mol Biol, Buffalo, NY 14260 USA 5. Univ Calif San Diego, Sch Med, Dept Neurosci, La Jolla, CA 92093 USA 6. CNR, Inst Genet & Biophys, Naples, Italy 7. Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland (literal)
Titolo
  • Mouse Models for Down Syndrome-Associated Developmental Cognitive Disabilities (literal)
Abstract
  • Down syndrome (DS) is mainly caused by the presence of an extra copy of human chromosome 21 (Hsa21) and is a leading genetic cause for developmental cognitive disabilities in humans. The mouse is a premier model organism for DS because the regions on Hsa21 are syntenically conserved with three regions in the mouse genome, which are located on mouse chromosome 10 (Mmu10), Mmu16 and Mmu17. With the advance of chromosomal manipulation technologies, new mouse mutants have been generated to mimic DS at both the genotypic and phenotypic levels. Further mouse-based molecular genetic studies in the future may lead to the unraveling of the mechanisms underlying DS-associated developmental cognitive disabilities, which would lay the groundwork for developing effective treatments for this phenotypic manifestation. In this review, we will discuss recent progress and future challenges in modeling DS-associated developmental cognitive disability in mice with an emphasis on hippocampus-related phenotypes. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it