Survivin promoter-31G/C polymorphism in oral cancer cell lines (Articolo in rivista)

Type
Label
  • Survivin promoter-31G/C polymorphism in oral cancer cell lines (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.3892/ol.2011.358 (literal)
Alternative label
  • De Maria, Salvatore; Lo Muzio, Lorenzo; Braca, Alessandra; Rega, Paolo; Cassano, Amalia; Vinella, Angela; Fumarulo, Ruggiero; Serpico, Rosario; Farina, Ernesto; Metafora, Vittoria; Pannone, Giuseppe; Ravagnan, Gian Pietro; Metafora, Salvatore; Rubini, Corrado; Carteni, Maria; Mariggio, Maria Addolorata (2011)
    Survivin promoter-31G/C polymorphism in oral cancer cell lines
    in Oncology Letters
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • De Maria, Salvatore; Lo Muzio, Lorenzo; Braca, Alessandra; Rega, Paolo; Cassano, Amalia; Vinella, Angela; Fumarulo, Ruggiero; Serpico, Rosario; Farina, Ernesto; Metafora, Vittoria; Pannone, Giuseppe; Ravagnan, Gian Pietro; Metafora, Salvatore; Rubini, Corrado; Carteni, Maria; Mariggio, Maria Addolorata (literal)
Pagina inizio
  • 935 (literal)
Pagina fine
  • 939 (literal)
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  • 2 (literal)
Rivista
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  • PMID (literal)
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  • 5 (literal)
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  • 5 (literal)
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  • Pubblicazione (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • ISI Web of Science (WoS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Seconda Universita degli Studi di Napoli; University of Foggia; IRCCS CROB; University of Bari; Seconda Universita degli Studi di Napoli; Consiglio Nazionale delle Ricerche (CNR); Universita Ca Foscari Venezia; Osped Molinette Ancona (literal)
Titolo
  • Survivin promoter-31G/C polymorphism in oral cancer cell lines (literal)
Abstract
  • Survivin (SVV) is a protein that belongs to the inhibitor of apoptosis proteins (IAP) family and is involved in the G2/M phase progression of the cell cycle as a spindle-associated molecule. The biological features of this protein are well documented and its activity appears to be involved in mitochondria-dependent and -independent antiapoptotic pathways. Overexpression of SVV at the transcriptional and translational level has been associated with cancer, a multifactorial disorder in which the occurrence of a -31G to C polymorphism in the promoter region may significantly contribute to the development of this pathology. To verify this hypothesis, the occurrence of a single nucleotide polymorphism (SNP) in cis-acting cell cycle-dependent elements (CDEs) and in cell cycle homology regions (CHRs) of the survivin TATA-less promoter was investigated. A total of 23 oral squamous cell carcinoma (OSCC) cell lines and normal epithelium-derived normal human epidermal keratinocyte (NHEK) cell lines were analyzed by RFLP and direct DNA sequencing of their promoter region. Furthermore, survivin expression at the transcriptional and translational levels was evaluated in these cells by RT-PCR and Western blotting, respectively. The findings indicate that the presence of a G or C allele is not directly correlated to survivin expression, at the mRNA or at the protein level, at least in the OSCC lines analyzed in this study. (literal)
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