The melatonin receptor 1a (MTNR1A) gene is associated with recurrent and idiopathic calcium nephrolithiasis (Articolo in rivista)

Type
Label
  • The melatonin receptor 1a (MTNR1A) gene is associated with recurrent and idiopathic calcium nephrolithiasis (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1093/ndt/gfr216 (literal)
Alternative label
  • Esposito T, Rendina D, Aloia A, Formicola D, Magliocca S, De Filippo G, Muscariello R, Mossetti G, Gianfrancesco F, Strazzullo P (2012)
    The melatonin receptor 1a (MTNR1A) gene is associated with recurrent and idiopathic calcium nephrolithiasis
    in Nephrology, dialysis, transplantation (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Esposito T, Rendina D, Aloia A, Formicola D, Magliocca S, De Filippo G, Muscariello R, Mossetti G, Gianfrancesco F, Strazzullo P (literal)
Pagina inizio
  • 2256 (literal)
Pagina fine
  • 2263 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • Esposito Teresa corresponding author (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 26 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • PMID: 21652546 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di genetica e biofisica \"Adriano Buzzati Traverso\", CNR, Naples, Italy (literal)
Titolo
  • The melatonin receptor 1a (MTNR1A) gene is associated with recurrent and idiopathic calcium nephrolithiasis (literal)
Abstract
  • Background. Metabolic syndrome is a risk factor for nephrolithiasis. This study was performed to evaluate the clinical and biochemical profile of calcium-oxalate nephrolithiasis in stone formers with metabolic syndrome. Methods. A total of 526 recurrent stone formers, 184 of them with metabolic syndrome, and 214 controls were examined on a free diet and after a sodium-restricted diet (sodium intake < 100 mmol/24 h). Results. On free diet, stone formers with metabolic syndrome showed higher sodium excretion [mean (95% confidence interval), 196 (176–218) vs 160 (150–168) mmol/24 h; P < 0.01] and lower citrate excretion [2.23 (1.99–2.58) vs 2.84 (2.51–3.17) mmol/24 h; P < 0.01] compared to controls, whereas stone formers without metabolic syndrome showed higher calcium and oxalate excretion [5.43 (5.01–5.82) vs 3.58 (2.84–4.19) and 0.34 (0.32–0.36) vs 0.26 (0.20–0.31) mmol/24 h for calcium and oxalate, respectively; P < 0.01] and lower citrate excretion [2.18 (1.98–2.38) vs 2.84 (2.51–3.17) mmol/24 h; P < 0.01] compared to controls. The ion activity product of urinary calcium-oxalate salts was similar between stone formers with and without metabolic syndrome [1.41 (1.31–1.59) vs 1.40 (1.35–1.45); P > 0.05]. After the test diet, this index was lower in diet-compliant stone formers with metabolic syndrome compared to diet-compliant stone formers without metabolic syndrome [1.15 (1.10–1.21) vs 1.39 (1.31–1.45); P < 0.01]. Conclusions. The biochemical profiles and responses to the sodium-restricted diet were significantly different between stone formers with metabolic syndrome and those without. Dietary habits play a central role in the pathogenesis of nephrolithiasis in stone formers with metabolic syndrome. (literal)
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