RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1101/gad.586710 (literal)

Alternative label

• Schaefer M, Pollex T, Hanna K, Tuorto F, Meusburger M, Helm M, Lyko F. (2010)
  RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage
  in Genes & development
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Schaefer M, Pollex T, Hanna K, Tuorto F, Meusburger M, Helm M, Lyko F. (literal)

Pagina inizio

• 1590 (literal)

Pagina fine

• 1595 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 24 (literal)

Rivista

• Genes & development (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• PMID:20679393 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Division of Epigenetics, DKFZ-ZMBH Alliance, German; Cancer Research Center, Heidelberg 69120, Germany; Institute of Genetics and Biophysics ABT, CNR, Naples 80131, Italy; Institute of Pharmacy and Molecular Biotechnology, Department of Chemistry, University of Heidelberg, Heidelberg 69210, Germany; Institute of Pharmacy, Johannes Gutenberg-University of Mainz, Mainz 55128, Germany (literal)

Titolo

• RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage (literal)

Abstract

• Dnmt2 proteins are the most conserved members of the DNA methyltransferase enzyme family, but their substrate specificity and biological functions have been a subject of controversy. We show here that, in addition to tRNA(Asp-GTC), tRNA(Val-AAC) and tRNA(Gly-GCC) are also methylated by Dnmt2. Drosophila Dnmt2 mutants showed reduced viability under stress conditions, and Dnmt2 relocalized to stress granules following heat shock. Strikingly, stress-induced cleavage of tRNAs was Dnmt2-dependent, and Dnmt2-mediated methylation protected tRNAs against ribonuclease cleavage. These results uncover a novel biological function of Dnmt2-mediated tRNA methylation, and suggest a role for Dnmt2 enzymes during the biogenesis of tRNA-derived small RNAs (literal)

Prodotto di

• Institute of genetics and biophysics \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Meccanismi molecolari e cellulari della determinazione neurale, differenziamento neuronale e patologie del sistema nervoso (SV.P16.006.001) (Modulo)

Autore CNR

• FRANCESCA TUORTO (Unità di personale interno)

Incoming links:

Prodotto

• Institute of genetics and biophysics \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Meccanismi molecolari e cellulari della determinazione neurale, differenziamento neuronale e patologie del sistema nervoso (SV.P16.006.001) (Modulo)

Autore CNR di

• FRANCESCA TUORTO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Genes & development (Rivista)