Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1038/nn.2661 (literal)

Alternative label

• Di Salvio M.; Di Giovannantonio L.G.; Acampora D.; Prosperi R.; Omodei D.; Prakash N.; Wurst W.; Simeone A. (2010)
  Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP
  in Nature neuroscience (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Di Salvio M.; Di Giovannantonio L.G.; Acampora D.; Prosperi R.; Omodei D.; Prakash N.; Wurst W.; Simeone A. (literal)

Pagina inizio

• 1481 (literal)

Pagina fine

• 1488 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 13 (literal)

Rivista

• Nature neuroscience (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• PMID: 21057506 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 12 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CEINGE Biotecnologie Avanzate, Naples, Italy. SEMM European School of Molecular Medicine, Naples site, Naples, Italy. Institute of Genetics and Biophysics \"A. Buzzati-Traverso,\" CNR, Naples, Italy. Dipartimento di Matematica e Statistica, Università degli Studi del Sannio, Benevento, Italy. Helmholtz Zentrum Munchen, Technische Universität Munnchen, Deutsches Zentrum fur Neurodegnerative Erkrankungen Munchen, Institute of Developmental Genetics, Munich/Neuherberg, Germany. Max Planck Institute of Psychiatry, Molecular Neurogenetics, Munich, Germany. (literal)

Titolo

• Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP (literal)

Abstract

• Mesencephalic-diencephalic dopaminergic neurons control locomotor activity and emotion and are affected in neurodegenerative and psychiatric diseases. The homeoprotein Otx2 is restricted to ventral tegmental area (VTA) neurons that are prevalently complementary to those expressing Girk2 and glycosylated active form of the dopamine transporter (Dat). High levels of glycosylated Dat mark neurons with efficient dopamine uptake and pronounced vulnerability to Parkinsonian degeneration. We found that Otx2 controls neuron subtype identity by antagonizing molecular and functional features of dorsal-lateral VTA, such as Girk2 and Dat expression. Otx2 limited the number of VTA neurons with efficient dopamine uptake and conferred resistance to the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-HCl (MPTP) neurotoxin. Ectopic Otx2 expression also provided neurons of the substantia nigra with efficient neuroprotection to MPTP. These findings indicate that Otx2 is required to specify neuron subtype identity in VTA and may antagonize vulnerability to the Parkinsonian toxin MPTP (literal)

Prodotto di

• Meccanismi molecolari e cellulari della determinazione neurale, differenziamento neuronale e patologie del sistema nervoso (SV.P16.006.001) (Modulo)
• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR

• DARIO ACAMPORA (Persona)
• ANTONIO SIMEONE (Persona)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Meccanismi molecolari e cellulari della determinazione neurale, differenziamento neuronale e patologie del sistema nervoso (SV.P16.006.001) (Modulo)

Autore CNR di

• ANTONIO SIMEONE (Persona)
• DARIO ACAMPORA (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nature neuroscience (Rivista)