The Role of Otx2 in Adult Mesencephalic-Diencephalic Dopaminergic Neurons (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The Role of Otx2 in Adult Mesencephalic-Diencephalic Dopaminergic Neurons (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s12035-010-8148-y (literal)

Alternative label

• Simeone A, Di Salvio M, Di Giovannantonio LG, Acampora D, Omodei D, Tomasetti C. (2011)
  The Role of Otx2 in Adult Mesencephalic-Diencephalic Dopaminergic Neurons
  in Molecular neurobiology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Simeone A, Di Salvio M, Di Giovannantonio LG, Acampora D, Omodei D, Tomasetti C. (literal)

Pagina inizio

• 107 (literal)

Pagina fine

• 113 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 43 (literal)

Rivista

• Molecular neurobiology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• PMID:21086067 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CEINGE Biotecnologie Avanzate, European School of Molecular Medicine, Via Comunale Margherita 482, 80145 Naples, Italy Institute of Genetics and Biophysics \"A. Buzzati-Traverso\", CNR,Via P. Castellino 111, 80131 Naples, Italy (literal)

Titolo

• The Role of Otx2 in Adult Mesencephalic-Diencephalic Dopaminergic Neurons (literal)

Abstract

• Mesencephalic and diencephalic dopaminergic (mdDA) progenitors generate two major groups of neurons corresponding to the A9 neurons of the substantia nigra pars compacta (SNpc) and the A10 neurons of the ventral tegmental area (VTA). MdDA neurons control motor, sensorimotor and motivated behaviour and their degeneration or abnormal functioning is associated to Parkinson's disease and psychiatric disorders. Although relevant advances have been made, the molecular basis controlling identity, survival and vulnerability to neurodegeneration of SNpc and VTA neurons remains poorly understood. Here, we will review recent findings on the role exerted by the transcription factor Otx2 in adult mdDA neurons. Otx2 expression is restricted to a relevant fraction of VTA neurons and absent in the SNpc. In particular, Otx2 is prevalently excluded from neurons of the dorsal-lateral VTA, which expressed Girk2 and high level of the dopamine transporter (Dat). Loss and gain of function mouse models revealed that Otx2 controls neuron subtype identity by antagonizing molecular and functional features of the dorsal-lateral VTA such as Girk2 and Dat expression as well as vulnerability to the parkinsonian MPTP toxin. Furthermore, when ectopically expressed in the SNpc, Otx2 suppresses Dat expression and confers efficient neuroprotection to MPTP toxicity by suppressing efficient DA uptake. (literal)

Prodotto di

• Meccanismi molecolari e cellulari della determinazione neurale, differenziamento neuronale e patologie del sistema nervoso (SV.P16.006.001) (Modulo)
• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR

• DARIO ACAMPORA (Persona)
• ANTONIO SIMEONE (Persona)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Meccanismi molecolari e cellulari della determinazione neurale, differenziamento neuronale e patologie del sistema nervoso (SV.P16.006.001) (Modulo)

Autore CNR di

• ANTONIO SIMEONE (Persona)
• DARIO ACAMPORA (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecular neurobiology (Rivista)