The role of Otx genes in progenitor domains of ventral midbrain (Articolo in rivista)

Type
Label
  • The role of Otx genes in progenitor domains of ventral midbrain (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Alternative label
  • Simeone A, Puelles E, Acampora D, Omodei D, Mancuso P, Giovanni Di Giovannantonio L (2009)
    The role of Otx genes in progenitor domains of ventral midbrain
    in Advances in experimental medicine and biology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Simeone A, Puelles E, Acampora D, Omodei D, Mancuso P, Giovanni Di Giovannantonio L (literal)
Pagina inizio
  • 36 (literal)
Pagina fine
  • 46 (literal)
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  • 651 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • PMID: 19731548 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CSIC, Inst Neurociencias Alicante, Sant Joan dAlacant, Spain Univ Miguel Hernandez, Sant Joan dAlacant, Spain CEINGE Biotecnol Avanzate SEMM European Sch Mol M, Naples, Italy Int Inst Genet & Biophys, I-80125 Naples, Italy (literal)
Titolo
  • The role of Otx genes in progenitor domains of ventral midbrain (literal)
Abstract
  • The mesencephalic dopaminergic (mesDA) neurons play a relevant role in the control of movement, behaviour and cognition. Indeed loss and/or abnormal development of mesDA neurons is responsible for Parkinson's disease as well as for addictive and psychiatric disorders. A wealth of information has been provided on gene functions involved in the molecular mechanism controlling identity, face and survival of mesDA neurons. Collectively, these studies are contributing to a growing knowledge of the genetic networks required for proper mesDA development, thus disclosing new perspectives for therapeutic approaches of mesDA disorders. Here we will focus on the control exerted by Otx genes in early decisions regulating the differentiation of progenitors located in the ventral midbrain. In this context, the regulatory network involving Otx functional interactions with signalling molecules and transcription factors required to promote or prevent the development of mesDA neurons will be analyzed in derail. (literal)
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