Role of placental growth factor and its receptor Flt-1 in rheumatoid inflammation: A link between angiogenesis and inflammation (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Role of placental growth factor and its receptor Flt-1 in rheumatoid inflammation: A link between angiogenesis and inflammation (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/art.24289 (literal)

Alternative label

• Yoo S.A.; Yoon H.J.; Kim H.S.; Chae C.B.; De Falco S.; Cho C.S.; Kim W.U. (2009)
  Role of placental growth factor and its receptor Flt-1 in rheumatoid inflammation: A link between angiogenesis and inflammation
  in Arthritis and rheumatism; Wiley-Liss, New York (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Yoo S.A.; Yoon H.J.; Kim H.S.; Chae C.B.; De Falco S.; Cho C.S.; Kim W.U. (literal)

Pagina inizio

• 345 (literal)

Pagina fine

• 354 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://onlinelibrary.wiley.com/doi/10.1002/art.24289/abstract (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 60 (literal)

Rivista

• Arthritis and rheumatism (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• PMID: 19180491 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Catholic Univ Korea, Seoul, South Korea; Konkuk Univ, Seoul, South Korea; CNR, Inst Genet & Biophys Adriano Buzzati Traverso, I-80125 Naples, Italy (literal)

Titolo

• Role of placental growth factor and its receptor Flt-1 in rheumatoid inflammation: A link between angiogenesis and inflammation (literal)

Abstract

• Objective. To investigate the direct effects of placenta growth factor (PIGF) and its specific receptor, flt-1, which are known to mediate angiogenesis, on the inflammatory process of rheumatoid arthritis (RA). Methods. Expression of PIGF and flt-1 in the synovial tissue of RA patients was examined using immunohistochemistry. Enzyme-linked immunosorbent assay was used to determine the concentrations of PIGF, tumor necrosis factor alpha (TNF alpha), and interleukin-6 (IL-6) in culture supernatants of either mononuclear cells or synoviocytes. The flt-1. expression level in mononuclear cells was analyzed by flow cytometry. Experimental arthritis was induced in mice either by immunization with type II collagen (CII) or by injection of anti-CII antibody. Results. PIGF was highly expressed in the synovium of RA patients, and its primary source was fibroblast-like synoviocytes (FLS). When stimulated with 1L-1 beta, FLS from RA patients produced higher amounts of PIGF than did FLS from patients with osteoarthritis. Exogenous PIGF specifically increased the production of TNF alpha and IL-6 in mononuclear cells from RA patients (but not those from healthy controls) via a calcineurin-dependent pathway. The response to PIGF was associated with increased expression of flt-1 on RA monocytes, which could be induced by IL-1 beta and TNFa. A novel anti-flt-1 hexapeptide, GNQWFI, abrogated the PIGF-induced increase in TNFa and IL-6 production, and also suppressed CII-induced arthritis and serum IL-6 concentrations in mice. Moreover, genetic ablation of PIGF prevented the development of anti-CII antibody-induced arthritis in mice. Conclusion. Our data suggest that enhanced expression of PIGF and flt-1 may contribute to rheumatoid inflammation by triggering production of proinflammatory cytokines. The use of the novel anti-flt-1 peptide, GNQWFI, may be an effective strategy for the treatment of RA. (literal)

Editore

• Wiley-Liss (Editore)

Prodotto di

• Identificazione di regolatori del differenziamento, della motilità e dell'apoptosi delle cellule staminali (SV.P15.008.001) (Modulo)
• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR

• SANDRO DE FALCO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Role of placental growth factor and its receptor Flt-1 in rheumatoid inflammation: A link between angiogenesis and inflammation" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Identificazione di regolatori del differenziamento, della motilità e dell'apoptosi delle cellule staminali (SV.P15.008.001) (Modulo)

Autore CNR di

• SANDRO DE FALCO (Unità di personale interno)

Editore di

• Wiley-Liss (Editore)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Arthritis and rheumatism (Rivista)

Insieme di parole chiave di

• Keywords of "Role of placental growth factor and its receptor Flt-1 in rheumatoid inflammation: A link between angiogenesis and inflammation" (Insieme di parole chiave)