Coupling meiotic chromosome axis integrity to recombination (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Coupling meiotic chromosome axis integrity to recombination (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1101/gad.459308 (literal)

Alternative label

• Storlazzi A.; Tesse S.; Ruprich-Robert G.; Gargano S.; Poeggeler S.; Kleckner N.; Zickler D. (2008)
  Coupling meiotic chromosome axis integrity to recombination
  in Genes & development
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Storlazzi A.; Tesse S.; Ruprich-Robert G.; Gargano S.; Poeggeler S.; Kleckner N.; Zickler D. (literal)

Pagina inizio

• 796 (literal)

Pagina fine

• 809 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 22 (literal)

Rivista

• Genes & development (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 6 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Universite´ Paris-Sud, 91405 Orsay Cedex, France; Istituto di Genetica e Biofisica A. Buzzati Traverso, Centro Nazionale di Recherca, 80125 Napoli, Italy; Institut für Mikrobiologie und Genetik,Georg-August Universität, 37077 Göttingen, Germany; Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA (literal)

Titolo

• Coupling meiotic chromosome axis integrity to recombination (literal)

Abstract

• During meiosis, DNA events of recombination occur in direct physical association with underlying chromosome axes. Meiotic cohesin Rec8 and cohesin-associated Spo76/Pds5 are prominent axis components. Two observations indicate that recombination complexes can direct the local destabilization of underlying chromosome axes. First, in the absence of Rec8, Spo76/Pds5 is lost locally at sites of late-persisting Msh4 foci, with a concomitant tendency for loosening of intersister and interhomolog connectedness at the affected sites. This loss is dependent on initiation of recombination. Second, in wild-type prophase, local separation of sister axes is seen at sites of synaptonemal complex-associated recombination nodules. Additional findings reveal that Rec8 localizes to both axis and bulk chromatin and is required for chromatin compactness. Further, Rec8 is essential for maintenance of sister cohesion, along arms and centromeres, during the pachytene-to-diplotene transition, revealing an intrinsic tendency for destabilization of sister cohesion during this period. This finding shows how the loss of sister connectedness, in arm and/or centric regions, could lead to the segregation defects that are seen in the human \"maternal age effect\" and how Rec8 could be a target of that effect. Finally, Rec8 plays related, but synergistic roles with Spo76/Pds5, indicating auxiliary roles for meiotic and mitotic cohesion-associated components. (literal)

Prodotto di

• Sviluppo e funzionamento dei sistemi complessi - Uso di modelli biologici (SV.P16.005.001) (Modulo)
• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR

• AURORA STORLAZZI (Unità di personale interno)
• SILVANA GARGANO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Coupling meiotic chromosome axis integrity to recombination" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Sviluppo e funzionamento dei sistemi complessi - Uso di modelli biologici (SV.P16.005.001) (Modulo)

Autore CNR di

• SILVANA GARGANO (Unità di personale interno)
• AURORA STORLAZZI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Genes & development (Rivista)

Insieme di parole chiave di

• Keywords of "Coupling meiotic chromosome axis integrity to recombination" (Insieme di parole chiave)