Cripto as a target for improving embryonic stem cell-based therapy in Parkinson's disease (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Cripto as a target for improving embryonic stem cell-based therapy in Parkinson's disease (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1634/stemcells.2004-0294 (literal)

Alternative label

• Parish C.L.; Parisi S.; Persico M.G.: Arenas E.; Minchiotti G. (2005)
  Cripto as a target for improving embryonic stem cell-based therapy in Parkinson's disease
  in Stem cells (Dayt. Ohio)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Parish C.L.; Parisi S.; Persico M.G.: Arenas E.; Minchiotti G. (literal)

Pagina inizio

• 471 (literal)

Pagina fine

• 476 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://onlinelibrary.wiley.com/doi/10.1634/stemcells.2004-0294/abstract;jsessionid=DB80E64732479BBDDF253322BC8594E7.d01t01 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 23 (literal)

Rivista

• Stem cells (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden; Institute of Genetics and Biophysics \"A. Buzzati-Traverso,\" CNR, Naples, Italy (literal)

Titolo

• Cripto as a target for improving embryonic stem cell-based therapy in Parkinson's disease (literal)

Abstract

• Embryonic stem (ES) cells have been suggested as candidate therapeutic tools for cell replacement therapy in neurodegenerative disorders. However, limitations for the use of these cells lie in our restricted knowledge of the molecular mechanisms involved in their specialized differentiation and in the risk of tumor formation. Recent findings suggest that the EGF-CFC protein Cripto is a key player in the signaling pathways controlling neural induction in ES cells. Here we show that in vitro differentiation of Cripto(-/-) ES cells results in increased dopaminergic differentiation and that, upon transplantation into Parkinsonian rats, they result in behavioral and anatomical recovery with no tumor formation. The use of knockout ES cells that can generate dopamine cells while eliminating tumor risk holds enormous potential for cell replacement therapy in Parkinson's disease. (literal)

Prodotto di

• Identificazione di regolatori del differenziamento, della motilità e dell'apoptosi delle cellule staminali (SV.P15.008.001) (Modulo)
• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR

• GABRIELLA MINCHIOTTI (Persona)
• MARIA PERSICO (Persona)

Insieme di parole chiave

• Parole chiave di "Cripto as a target for improving embryonic stem cell-based therapy in Parkinson's disease" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Identificazione di regolatori del differenziamento, della motilità e dell'apoptosi delle cellule staminali (SV.P15.008.001) (Modulo)

Autore CNR di

• GABRIELLA MINCHIOTTI (Persona)
• MARIA PERSICO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Stem cells (Rivista)

Insieme di parole chiave di

• Parole chiave di "Cripto as a target for improving embryonic stem cell-based therapy in Parkinson's disease" (Insieme di parole chiave)